Allosteric role of a structural NADP
G6PD
NADPH
allostery
cryo-EM
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
19 07 2022
19 07 2022
Historique:
entrez:
20
7
2022
pubmed:
21
7
2022
medline:
23
7
2022
Statut:
ppublish
Résumé
Human glucose-6-phosphate dehydrogenase (G6PD) is the main cellular source of NADPH, and thus plays a key role in maintaining reduced glutathione to protect cells from oxidative stress disorders such as hemolytic anemia. G6PD is a multimeric enzyme that uses the cofactors β-D-glucose 6-phosphate (G6P) and "catalytic" NADP
Identifiants
pubmed: 35858355
doi: 10.1073/pnas.2119695119
pmc: PMC9303983
doi:
Substances chimiques
NADP
53-59-8
G6PD protein, human
EC 1.1.1.49
Glucosephosphate Dehydrogenase
EC 1.1.1.49
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2119695119Subventions
Organisme : NIA NIH HHS
ID : P01 AG031862
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM132039
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA243520
Pays : United States
Références
Biochem Biophys Res Commun. 1970 Apr 8;39(1):142-8
pubmed: 4392409
Trends Biochem Sci. 2014 Aug;39(8):347-54
pubmed: 25037503
Acta Crystallogr D Biol Crystallogr. 2005 May;61(Pt 5):495-504
pubmed: 15858258
J Comput Chem. 2004 Oct;25(13):1605-12
pubmed: 15264254
Blood Cells Mol Dis. 2012 Mar 15;48(3):154-65
pubmed: 22293322
Pharmacol Ther. 2021 Jun;222:107788
pubmed: 33326820
IUBMB Life. 2012 May;64(5):362-9
pubmed: 22431005
Structure. 2000 Mar 15;8(3):293-303
pubmed: 10745013
Protein Sci. 2008 Aug;17(8):1403-11
pubmed: 18493020
Arch Biochem Biophys. 1971 Dec;147(2):493-501
pubmed: 4400167
Proc Natl Acad Sci U S A. 2021 Jan 26;118(4):
pubmed: 33468660
Lancet. 2008 Jan 5;371(9606):64-74
pubmed: 18177777
Bull World Health Organ. 1989;67(6):601-11
pubmed: 2633878
Am J Hematol. 1993 Jan;42(1):53-8
pubmed: 8416297
FEBS Lett. 2017 May;591(9):1278-1284
pubmed: 28370139
Int J Mol Sci. 2016 Dec 09;17(12):
pubmed: 27941691
Cardiovasc Hematol Disord Drug Targets. 2013 Mar 1;13(1):73-82
pubmed: 23534950
Front Pharmacol. 2021 Mar 15;12:638885
pubmed: 33790795
Biochemistry. 1998 Mar 3;37(9):2759-67
pubmed: 9485426
Hematol Oncol Clin North Am. 2016 Apr;30(2):373-93
pubmed: 27040960
J Mol Med (Berl). 1998 Jul;76(8):581-8
pubmed: 9694435
Free Radic Res. 2014 Sep;48(9):1028-48
pubmed: 24720642
J Appl Microbiol. 2017 Oct;123(4):798-809
pubmed: 28609580
Cell Metab. 2021 Jan 5;33(1):94-109.e8
pubmed: 33159852
Biol Rev Camb Philos Soc. 2015 Aug;90(3):927-63
pubmed: 25243985