Antifungal activity of dehydrocurvularin for Candida spp. through the inhibition of adhesion to human adenocarcinoma cells.
Journal
The Journal of antibiotics
ISSN: 1881-1469
Titre abrégé: J Antibiot (Tokyo)
Pays: England
ID NLM: 0151115
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
received:
28
03
2022
accepted:
01
07
2022
revised:
27
06
2022
pubmed:
22
7
2022
medline:
11
8
2022
entrez:
21
7
2022
Statut:
ppublish
Résumé
Cell adhesion plays a crucial role in candidiasis through invasion of the human body and obtaining resistance to drugs by forming biofilms. Cell adhesion thus is a critical target for combating candidiasis by preventing the entry of fungal hyphae into the epithelium. We report here that dehydrocurvularin (1), isolated from the marine-derived fungus Curvularia aeria, exhibited anti-fungal activities for Candida albicans and Candida auris. This compound also prevented the adherence of C. albicans to human adenocarcinoma cells. Real-time RT-PCR analysis showed that exposure to 1 results in decreased expression of HWP1, EFG1, and ECE1, genes involved in Candida adhesion to epithelial cells and hyphal morphogenesis.
Identifiants
pubmed: 35859164
doi: 10.1038/s41429-022-00543-5
pii: 10.1038/s41429-022-00543-5
doi:
Substances chimiques
Antifungal Agents
0
Fungal Proteins
0
dehydrocurvularin
21178-57-4
Zearalenone
5W827M159J
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
530-533Subventions
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : JP20K16029
Informations de copyright
© 2022. The Author(s), under exclusive licence to the Japan Antibiotics Research Association.
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