T and B Cell Composition and Cytokine Producing Capacity Before and After Bariatric Surgery.
B cells Immune function and bariatric surgery
T cells
bariatric surgery
cytokine producing capacity
immune cell function
morbid obesity
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
02
03
2022
accepted:
31
05
2022
entrez:
21
7
2022
pubmed:
22
7
2022
medline:
23
7
2022
Statut:
epublish
Résumé
Morbid obesity is associated with a chronic state of low-grade inflammation, which may lead to accelerated differentiation of T and B cells. These differentiated immune cells are strongly cytotoxic and have an increased pro-inflammatory cytokine producing capacity. Furthermore, the anti-inflammatory function of the T and B cells decreases. The aim of this study was to evaluate the effect of morbid obesity on the subset profile and cytokine producing capacity of T and B cells. Subsequently, we assessed whether bariatric surgery affected the subset profile and cytokine producing capacity of these cells. We determined the proportion of T and B cell subsets and their cytokine producing capacity in peripheral blood collected from 23 morbidly obese patients before and three months after bariatric surgery using flow-cytometry. We compared this with the results of 25 lean controls. Both CD4+ and CD8+ T cells showed a more differentiated subset profile in morbidly obese patients as compared to lean controls, which was not recovered three months after bariatric surgery. The B cell composition of morbidly obese patients after bariatric surgery adjusted towards the profile of lean controls. However, the IL-2 and IFN-γ producing capacity of CD8+ T cells and the IL-2, IFN-γ, TNF-α and IL-10 producing capacity of B cells was not restored three months after bariatric surgery. In conclusion, the data suggest that the immune system has the capacity to recover from the detrimental effects of morbid obesity within three months after bariatric surgery in terms of cell composition; however, this was not seen in terms of cytokine producing capacity. The full restoration of the immune system after bariatric surgery may thus take longer.
Identifiants
pubmed: 35860273
doi: 10.3389/fimmu.2022.888278
pmc: PMC9289114
doi:
Substances chimiques
Cytokines
0
Interleukin-2
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
888278Informations de copyright
Copyright © 2022 Wijngaarden, Taselaar, Nuijten, Harst, Klaassen, Kuijper, Jongbloed, Ambagtsheer, Klepper, IJzermans, de Bruin and Litjens.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Front Immunol. 2020 Sep 02;11:2060
pubmed: 32983154
Int J Obes (Lond). 2019 Nov;43(11):2189-2199
pubmed: 30979972
Gastroenterology. 2007 May;132(6):2253-71
pubmed: 17498516
Oxid Med Cell Longev. 2019 Dec 6;2019:3940739
pubmed: 31885787
Diabetes. 2009 Nov;58(11):2525-35
pubmed: 19690064
Diabetes. 2012 Feb;61(2):401-8
pubmed: 22228716
Stat Med. 2019 May 30;38(12):2248-2268
pubmed: 30761571
FASEB J. 2016 May;30(5):1987-99
pubmed: 26873938
Minerva Endocrinol. 2018 Mar;43(1):87-100
pubmed: 28206728
Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5133-8
pubmed: 23479618
Nat Med. 2011 May;17(5):610-7
pubmed: 21499269
Front Immunol. 2019 Oct 29;10:2555
pubmed: 31736971
Immun Ageing. 2012 Jul 25;9(1):15
pubmed: 22830639
Curr Obes Rep. 2014 Dec;3(4):422-31
pubmed: 26626919
N Engl J Med. 2007 May 24;356(21):2176-83
pubmed: 17522401
Exp Gerontol. 2002 Jan-Mar;37(2-3):445-53
pubmed: 11772532
J Immunol Methods. 2008 Jan 31;330(1-2):1-11
pubmed: 18061610
Curr Opin Immunol. 2009 Aug;21(4):440-5
pubmed: 19535233
Surg Obes Relat Dis. 2017 Feb;13(2):170-180
pubmed: 27720197
Cell Metab. 2013 Nov 5;18(5):759-766
pubmed: 24209772
Cell Metab. 2021 Aug 3;33(8):1610-1623.e5
pubmed: 34256015
Am J Clin Nutr. 2011 Aug;94(2):450-8
pubmed: 21677057
Clin Exp Immunol. 2013 Oct;174(1):179-91
pubmed: 23750604
Clin Exp Pharmacol Physiol. 2017 May;44(5):556-565
pubmed: 28222218
Front Immunol. 2018 Feb 09;9:169
pubmed: 29479350
Int Arch Allergy Immunol. 2022;183(5):566-571
pubmed: 35081529
Mech Ageing Dev. 2009 Oct;130(10):681-90
pubmed: 19698733
Clin Exp Immunol. 2010 Nov;162(2):271-9
pubmed: 20854328
J Invest Dermatol. 2009 Feb;129(2):266-77
pubmed: 19148216
Obesity (Silver Spring). 2016 Mar;24(3):615-25
pubmed: 26857091
J Clin Invest. 1995 May;95(5):2409-15
pubmed: 7738205
Circ Res. 2016 May 27;118(11):1844-55
pubmed: 27230645
Metabolism. 2016 Nov;65(11):1614-1620
pubmed: 27733249
Trends Cardiovasc Med. 2016 May;26(4):364-73
pubmed: 26654259
Mol Cells. 2014 May;37(5):365-71
pubmed: 24781408
Int J Obes. 1985;9(3):155-70
pubmed: 3840463
Cardiovasc Res. 2017 Jul 1;113(9):1009-1023
pubmed: 28838042
J Immunol. 2010 Aug 1;185(3):1836-45
pubmed: 20581149
Diabetes Metab Syndr. 2016 Jan-Mar;10(1 Suppl 1):S34-41
pubmed: 26482966
JAMA. 1999 Oct 27;282(16):1523-9
pubmed: 10546691
Surg Obes Relat Dis. 2017 Apr;13(4):594-599
pubmed: 28159564
Eur J Immunol. 2013 Nov;43(11):2797-809
pubmed: 24258910
J Endocrinol. 2014 Jan 08;220(2):T47-59
pubmed: 24403378
Int Immunopharmacol. 2017 Feb;43:16-22
pubmed: 27936460
World J Surg. 2008 Jul;32(7):1462-5
pubmed: 18368447
Annu Rev Immunol. 2004;22:745-63
pubmed: 15032595
FEBS Lett. 2005 Apr 11;579(10):2035-9
pubmed: 15811314
Blood. 2009 Oct 29;114(18):3803-12
pubmed: 19721009
J Immunol Res. 2016;2016:8426874
pubmed: 27493973
Circ Res. 2008 Aug 29;103(5):467-76
pubmed: 18658050
Int J Surg. 2020 Apr;76:101-110
pubmed: 32151750
Immunotherapy. 2020 Jun;12(8):541-544
pubmed: 32345093