Serum Neurofilament Light Chain in Patients With Atrial Fibrillation.
ECG
atrial fibrillation
brain health
neurofilament light chain
pathophysiology
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
19 07 2022
19 07 2022
Historique:
entrez:
21
7
2022
pubmed:
22
7
2022
medline:
26
7
2022
Statut:
ppublish
Résumé
Background Atrial fibrillation (AF) is associated with stroke and MRI features of cerebral tissue damage but its impact on levels of serum neurofilament light chain (sNFL), an established biochemical marker of neuroaxonal damage, is unknown. Methods and Results In this observational study, sNFL was analyzed in 280 patients with AF and 280 controls without AF matched for age, sex, and diabetes status within the STABILITY (Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy) trial. None of the patients had a history of previous stroke or transient ischemic attack. Patients with a diagnosis of AF were divided into two groups based on if they were in AF rhythm at the time of blood sampling (AF ECG+, n=74), or not (AF ECG-, n=206). Multiple linear regression analysis was performed to adjust for clinical risk factors. In patients with AF, the levels of sNFL were 15% (AF ECG+) and 10% (AF ECG-) higher than in the control group after adjustment for clinical risk factors,
Identifiants
pubmed: 35861814
doi: 10.1161/JAHA.122.025910
pmc: PMC9707825
doi:
Substances chimiques
Anticoagulants
0
Biomarkers
0
Banques de données
ClinicalTrials.gov
['NCT00799903']
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e025910Références
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