Identification of zebrafish PLEKHF2 presents in egg/embryos as an antibacterial protein.

Animals Anti-Bacterial Agents / pharmacology Bacteria / metabolism Lipopolysaccharides / metabolism Receptors, Pattern Recognition Zebrafish Zebrafish Proteins / metabolism
Antibacterial activity PLEKHF2 proteins Pattern recognition receptor

Journal

Fish & shellfish immunology
ISSN: 1095-9947
Titre abrégé: Fish Shellfish Immunol
Pays: England
ID NLM: 9505220

Informations de publication

Date de publication:
Aug 2022
Historique:
received: 15 02 2022
revised: 06 07 2022
accepted: 13 07 2022
pubmed: 22 7 2022
medline: 18 8 2022
entrez: 21 7 2022
Statut: ppublish

Résumé

PLEKHF2 proteins are widespread in animals, but their functions and mechanisms remain poorly defined. Here we clearly demonstrate that PLEKHF2 is a newly identified present abundantly in the eggs/embryos of zebrafish. We also show that recombinant PLEKHF2 acts as a pattern recognition receptor capable of identifying the bacterial signature molecule PGN, LPS, and LTA, binding the bacteria, and functions as an antibacterial effector directly killing the bacteria. In brief, these results indicate that PLEKHF2 is an antibacterial protein, a novel role assigned to PLEKHF2 proteins.

Identifiants

DOI: 10.1016/j.fsi.2022.07.038 PMID: 35863537
pubmed: 35863537
pii: S1050-4648(22)00427-2
doi: 10.1016/j.fsi.2022.07.038
pii:
doi:

Substances chimiques

Anti-Bacterial Agents 0
Lipopolysaccharides 0
Receptors, Pattern Recognition 0
Zebrafish Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

925-932

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Auteurs

Yiqing Ren (Y)

Shandong Provincial Key Laboratory of Biochemical Engineering, College of Marine Science and Biological Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China.

Chunqiu Wang (C)

Shandong Provincial Key Laboratory of Biochemical Engineering, College of Marine Science and Biological Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China.

Hao Wang (H)

Shandong Provincial Key Laboratory of Biochemical Engineering, College of Marine Science and Biological Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China.

Qingqi Chang (Q)

Shandong Provincial Key Laboratory of Biochemical Engineering, College of Marine Science and Biological Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China.

Dongqiu Guo (D)

Shandong Provincial Key Laboratory of Biochemical Engineering, College of Marine Science and Biological Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China.

Xia Wang (X)

Shandong Provincial Key Laboratory of Biochemical Engineering, College of Marine Science and Biological Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China. Electronic address: wxbiology@qust.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Identification of zebrafish PLEKHF2 presents...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Identification of zebrafish PLEKHF2 presents...
questionsmedicales.fr › Bactéries › Identification of zebrafish PLEKHF2 presents...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Toxines bactériennes › Endotoxines › Lipopolysaccharides › Identification of zebrafish PLEKHF2 presents...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs de reconnaissance de motifs moléculaires › Identification of zebrafish PLEKHF2 presents...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › Identification of zebrafish PLEKHF2 presents...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de poisson › Protéines de poisson-zèbre › Identification of zebrafish PLEKHF2 presents...