Effect of sodium lauryl sulfate-mediated gelation on the suppressed dissolution of crystalline lurasidone hydrochloride and a strategy to mitigate the gelation.
Dissolution
Gelation
Lurasidone hydrochloride
Sodium lauryl sulfate
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
25 Aug 2022
25 Aug 2022
Historique:
received:
22
04
2022
revised:
05
07
2022
accepted:
16
07
2022
pubmed:
22
7
2022
medline:
17
8
2022
entrez:
21
7
2022
Statut:
ppublish
Résumé
In dissolution test, the surfactant sodium lauryl sulfate (SLS) is usually added to increase the dissolution of insoluble drugs and achieve the sink condition. However, the current study found that 0.1 % SLS would significantly decrease the dissolution of crystalline lurasidone hydrochloride (LH, a BCS Ⅱ drug). The aim of this study was to clarify the mechanism of this unexpected phenomenon and explore a strategy for mitigating the negative effect of SLS on the dissolution of LH. Sample characterizations (such as PLM, DSC, PXRD, IR and NMR) confirmed that the insoluble single-phase amorphous LH-SLS complex (with a single T
Identifiants
pubmed: 35863597
pii: S0378-5173(22)00590-7
doi: 10.1016/j.ijpharm.2022.122035
pii:
doi:
Substances chimiques
Excipients
0
Micelles
0
Surface-Active Agents
0
Sodium Dodecyl Sulfate
368GB5141J
Lurasidone Hydrochloride
O0P4I5851I
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
122035Informations de copyright
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