Effects of Dexmedetomidine Anesthesia on Early Postoperative Cognitive Dysfunction in Elderly Patients.
dexmedetomidine (DEX)
inflammation
mini-mental state examination (MMSE)
postoperative cognitive dysfunction (POCD)
Journal
ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337
Informations de publication
Date de publication:
03 08 2022
03 08 2022
Historique:
pubmed:
22
7
2022
medline:
5
8
2022
entrez:
21
7
2022
Statut:
ppublish
Résumé
The stimulation of tracheal extraction and anesthesia may lead to early postoperative cognitive dysfunction (POCD) in elderly patients, especially within 72 h after surgery, due to the insufficient compensatory and regulatory effects of their cardiovascular system. This study was performed to demonstrate the effects of additional dexmedetomidine (DEX) administration on alleviating early POCD (72 h post intubation) and inflammation in elderly patients who underwent intubation. A parallel-randomized trial was performed in this study. A total of 100 patients aged 60-85 years were randomly divided into two groups (DEX,
Identifiants
pubmed: 35864562
doi: 10.1021/acschemneuro.2c00173
doi:
Substances chimiques
Dexmedetomidine
67VB76HONO
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM