CD169 (Siglec-1) as a Robust Human Cell Biomarker of Toll-Like Receptor 9 Agonist Immunotherapy.
CD169
HIV-1
biomarker
immunotherapy
toll-like receptor 9 (TLR9)
Journal
Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359
Informations de publication
Date de publication:
2022
2022
Historique:
received:
13
04
2022
accepted:
14
06
2022
entrez:
22
7
2022
pubmed:
23
7
2022
medline:
26
7
2022
Statut:
epublish
Résumé
Immunotherapy is a promising therapeutic area in cancer and chronic viral infections. An important component of immunotherapy in these contexts is the activation of innate immunity. Here we investigate the potential for CD169 (Siglec 1) expression on monocytes to serve as a robust biomarker for activation of innate immunity and, particular, as a proxy for IFN-α production. Specifically, we investigated the effects of
Identifiants
pubmed: 35865810
doi: 10.3389/fcimb.2022.919097
pmc: PMC9294151
doi:
Substances chimiques
Adjuvants, Immunologic
0
Biomarkers
0
Immunologic Factors
0
Sialic Acid Binding Ig-like Lectin 1
0
Toll-Like Receptor 9
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
919097Informations de copyright
Copyright © 2022 Lende, Pahus, Monrad, Olesen, Mahr, Vibholm, Østergaard, Søgaard, Andersen, Denton and Tolstrup.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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