An immature, dedifferentiated, and lineage-deconstrained cone precursor origin of N-Myc-initiated retinoblastoma.


Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
12 07 2022
Historique:
entrez: 22 7 2022
pubmed: 23 7 2022
medline: 27 7 2022
Statut: ppublish

Résumé

Most retinoblastomas develop from maturing cone precursors in response to biallelic

Identifiants

pubmed: 35867756
doi: 10.1073/pnas.2200721119
pmc: PMC9282279
doi:

Substances chimiques

MYCN protein, human 0
N-Myc Proto-Oncogene Protein 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2200721119

Subventions

Organisme : NCI NIH HHS
ID : P30 CA014089
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA137124
Pays : United States
Organisme : HHS | NIH | Center for Scientific Review (CSR)
ID : P30CA014089
Organisme : HHS | NIH | Center for Scientific Review (CSR)
ID : R01CA137124

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Auteurs

Hardeep P Singh (HP)

The Vision Center, Children's Hospital Los Angeles, Los Angeles, CA 90027.
The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027.
USC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.

Dominic W H Shayler (DWH)

The Vision Center, Children's Hospital Los Angeles, Los Angeles, CA 90027.
The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027.

G Esteban Fernandez (GE)

The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027.

Matthew E Thornton (ME)

Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.

Cheryl Mae Craft (CM)

USC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.
Department of Integrative Anatomical Sciences, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033.

Brendan H Grubbs (BH)

Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.

David Cobrinik (D)

The Vision Center, Children's Hospital Los Angeles, Los Angeles, CA 90027.
The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027.
USC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.
Department of Biochemistry & Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.
Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033.

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Classifications MeSH