Adenosine A
Adenosine A2 Receptor Antagonists
/ therapeutic use
Animals
Antineoplastic Agents
/ administration & dosage
Chemotherapy-Related Cognitive Impairment
/ prevention & control
Cisplatin
/ adverse effects
Cognition
/ drug effects
Hippocampus
/ drug effects
Mice
Mice, Inbred C57BL
Neural Stem Cells
/ drug effects
Neurogenesis
/ drug effects
Purines
/ administration & dosage
Receptor, Adenosine A2A
/ metabolism
KW-6002
adenosine A2A receptor
adult neurogenesis
chemobrain
chemotherapy-induced cognitive impairment
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
12 07 2022
12 07 2022
Historique:
entrez:
22
7
2022
pubmed:
23
7
2022
medline:
27
7
2022
Statut:
ppublish
Résumé
Chemotherapy-induced cognitive impairment (CICI) has emerged as a significant medical problem without therapeutic options. Using the platinum-based chemotherapy cisplatin to model CICI, we revealed robust elevations in the adenosine A
Identifiants
pubmed: 35867768
doi: 10.1073/pnas.2206415119
pmc: PMC9282426
doi:
Substances chimiques
Adenosine A2 Receptor Antagonists
0
Antineoplastic Agents
0
Purines
0
Receptor, Adenosine A2A
0
istradefylline
2GZ0LIK7T4
Cisplatin
Q20Q21Q62J
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2206415119Subventions
Organisme : NIA NIH HHS
ID : R01 AG058560
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA242158
Pays : United States
Organisme : HHS | NIH | National Institute on Aging (NIA)
ID : R01AG058560
Organisme : HHS | NIH | National Cancer Institute (NCI)
ID : R01CA242158
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