Olmesartan Ameliorates Organ Injury and Mortality in Rats With Peritonitis-Induced Sepsis.

Angiotensin II Type 1 Receptor Blockers Animals Cecum Disease Models, Animal Humans Imidazoles Interleukin-6 Nitric Oxide Olmesartan Medoxomil Peritonitis / complications Rats Rats, Wistar Sepsis / complications Tetrazoles
Inflammatory response Nitric oxide Olmesartan medoxomil Organ injury Polymicrobial sepsis

Journal

The Journal of surgical research
ISSN: 1095-8673
Titre abrégé: J Surg Res
Pays: United States
ID NLM: 0376340

Informations de publication

Date de publication:
11 2022
Historique:
received: 28 07 2021
revised: 05 05 2022
accepted: 06 05 2022
pubmed: 23 7 2022
medline: 24 9 2022
entrez: 22 7 2022
Statut: ppublish

Résumé

Sepsis and related complications lead to high morbidity and mortality in humans and animals. Olmesartan medoxomil (OLM), a nonpeptide angiotensin II type 1 receptor blocker, has antiinflammatory and antioxidative effects in various experimental animal models. The present study aimed to investigate whether OLM protects against sepsis in a clinically relevant model of polymicrobial sepsis induced by cecal ligation and puncture (CLP). Sepsis was induced by CLP in anesthetized rats. OLM was administered intraperitoneally 3 h after CLP onset. Hemodynamic, biochemical, and inflammatory parameters were analyzed. The administration of OLM in CLP rats significantly improved their survival rate. Moreover, OLM mitigated CLP-induced hypotension and organ injury (indicated by biochemical parameters), but not tachycardia. OLM significantly reduced the plasma levels of interleukin-6 and nitric oxide. OLM markedly attenuated CLP-induced hypotension and organ injury, and hence improved survival by inhibiting the inflammatory response and nitrosative stress in this clinically relevant model of sepsis.

Identifiants

DOI: 10.1016/j.jss.2022.05.034 PMID: 35868036
pubmed: 35868036
pii: S0022-4804(22)00352-3
doi: 10.1016/j.jss.2022.05.034
pii:
doi:

Substances chimiques

Angiotensin II Type 1 Receptor Blockers 0
Imidazoles 0
Interleukin-6 0
Tetrazoles 0
Nitric Oxide 31C4KY9ESH
Olmesartan Medoxomil 6M97XTV3HD
olmesartan 8W1IQP3U10

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

526-532

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Auteurs

Hsin-Jung Tsai (HJ)

Department of Anesthesiology, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Anesthesiology, Taipei Veterans General Hospital, Taipei, Taiwan.

Chih-Feng Chian (CF)

Division of Pulmonary and Critical Care, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Chih-Chin Shih (CC)

Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan.

Shiu-Jen Chen (SJ)

Department of Long-Term Care, University of Kang-Ning, Taipei, Taiwan.

Wen-Jinn Liaw (WJ)

Department of Anesthesiology, Chung Shan Medical University and Hospital, Taichung, Taiwan.

Hsieh-Chou Huang (HC)

Department of Anesthesiology and Pain Medicine, Cheng-Hsin General Hospital, Taipei, Taiwan.

Cheng-Ming Tsao (CM)

Department of Anesthesiology, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Anesthesiology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Anesthesiology, National Defense Medical Center, Taipei, Taiwan. Electronic address: cm.cmtsao@gmail.com.

Chin-Chen Wu (CC)

Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan. Electronic address: ccwu@mail.ndmctsgh.edu.tw.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antagonistes des récepteurs aux angiotensines › Antagonistes du récepteur de type 1 de l'angiotensine-II › Olmesartan Ameliorates Organ Injury and...
questionsmedicales.fr › Eucaryotes › Animaux › Olmesartan Ameliorates Organ Injury and...
questionsmedicales.fr › Système digestif › Tube digestif › Tube digestif inférieur › Gros intestin › Caecum › Olmesartan Ameliorates Organ Injury and...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Olmesartan Ameliorates Organ Injury and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Olmesartan Ameliorates Organ Injury and...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › Olmesartan Ameliorates Organ Injury and...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-6 › Olmesartan Ameliorates Organ Injury and...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Oxydes d'azote › Monoxyde d'azote › Olmesartan Ameliorates Organ Injury and...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Tétrazoles › Olmésartan médoxomil › Olmesartan Ameliorates Organ Injury and...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du péritoine › Péritonite › Olmesartan Ameliorates Organ Injury and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Olmesartan Ameliorates Organ Injury and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Wistar › Olmesartan Ameliorates Organ Injury and...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Sepsie › Olmesartan Ameliorates Organ Injury and...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Tétrazoles › Olmesartan Ameliorates Organ Injury and...