Antidiabetic lanostane triterpenoids from the fruiting bodies of Ganoderma weberianum.
Ganoderma weberianum
Lanostane triterpenoids
Molecular docking
α-glucosidase inhibitory activity
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
received:
02
03
2022
revised:
07
07
2022
accepted:
10
07
2022
pubmed:
23
7
2022
medline:
16
8
2022
entrez:
22
7
2022
Statut:
ppublish
Résumé
Eight previously undescribed lanostane triterpenoids, ganodeweberiols A ∼ H (1-8), together with eighteen known compounds (9-26), were isolated from the fruiting bodies of Ganoderma weberianum. The structures and absolute configurations of the new compounds were determined by extensive spectroscopic analysis, as well as NMR chemical shifts and electronic circular dichroism (ECD) calculations. Compounds 2, 7, 12, and 14 showed significant α-glucosidase inhibitory activity with IC
Identifiants
pubmed: 35868103
pii: S0045-2068(22)00431-X
doi: 10.1016/j.bioorg.2022.106025
pii:
doi:
Substances chimiques
Hypoglycemic Agents
0
Steroids
0
Triterpenes
0
Glucagon
9007-92-5
alpha-Glucosidases
EC 3.2.1.20
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
106025Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.