The interaction of hsa_circ_0002594 and eIF4A3 promotes T-helper 2 cell differentiation by the regulation of PTEN.
Asthma
Circ_0002594
PTEN
Th2 cell differentiation
eIF4A3
Journal
Clinical and experimental medicine
ISSN: 1591-9528
Titre abrégé: Clin Exp Med
Pays: Italy
ID NLM: 100973405
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
received:
11
05
2022
accepted:
06
07
2022
medline:
23
6
2023
pubmed:
24
7
2022
entrez:
23
7
2022
Statut:
ppublish
Résumé
T helper (Th) 2 cell-medicated immune response participates in various immune diseases, especially in asthma. Circ_0002594 has been reported to be up-regulated in asthmatic patients, and was higher in Th2-high subgroups, but the specific mechanisms by which circ_0002594 regulating Th2 cells were still unclear. Here, we found that circ_0002594 was significantly up-regulated in CD4
Identifiants
pubmed: 35870031
doi: 10.1007/s10238-022-00862-9
pii: 10.1007/s10238-022-00862-9
doi:
Substances chimiques
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
PTEN Phosphohydrolase
EC 3.1.3.67
Phosphatidylinositol 3-Kinases
EC 2.7.1.-
Interleukin-4
207137-56-2
TOR Serine-Threonine Kinases
EC 2.7.11.1
Cytokines
0
MicroRNAs
0
PTEN protein, human
EC 3.1.3.67
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
887-895Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
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