Pyruvate Supports RET-Dependent Mitochondrial ROS Production to Control
Mycobacterium avium infection
glycolysis
human primary macrophages
innate immunity
mitochondrial ROS
mitochondrial pyruvate
pyruvate
reverse electron transport
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
07
03
2022
accepted:
13
06
2022
entrez:
25
7
2022
pubmed:
26
7
2022
medline:
27
7
2022
Statut:
epublish
Résumé
Macrophages deploy a variety of antimicrobial programs to contain mycobacterial infection. Upon activation, they undergo extensive metabolic reprogramming to meet an increase in energy demand, but also to support immune effector functions such as secretion of cytokines and antimicrobial activities. Here, we report that mitochondrial import of pyruvate is linked to production of mitochondrial ROS and control of
Identifiants
pubmed: 35874747
doi: 10.3389/fimmu.2022.891475
pmc: PMC9298545
doi:
Substances chimiques
Reactive Oxygen Species
0
Pyruvic Acid
8558G7RUTR
Proto-Oncogene Proteins c-ret
EC 2.7.10.1
RET protein, human
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
891475Informations de copyright
Copyright © 2022 Røst, Louet, Bruheim, Flo and Gidon.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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