Insomnia disorder increases the risk of subjective memory decline in middle-aged and older adults: a longitudinal analysis of the Canadian Longitudinal Study on Aging.
CLSA
aging
cognition
cohort
insomnia
memory
Journal
Sleep
ISSN: 1550-9109
Titre abrégé: Sleep
Pays: United States
ID NLM: 7809084
Informations de publication
Date de publication:
09 11 2022
09 11 2022
Historique:
received:
24
03
2022
revised:
13
07
2022
pubmed:
26
7
2022
medline:
11
11
2022
entrez:
25
7
2022
Statut:
ppublish
Résumé
To examine the longitudinal association between probable insomnia status and both subjective and objective memory decline in middle-aged and older adults. 26 363 participants, ≥45 years, completed baseline and follow-up (3 years after baseline) self-reported evaluations of sleep and memory, and neuropsychological testing in the following cognitive domains: memory, executive functions, and psychomotor speed. Participants were categorized as having probable insomnia disorder (PID), insomnia symptoms only (ISO), or no insomnia symptoms (NIS), based on sleep questionnaires. Participants were further grouped based on their sleep change over time. Prospective odds of self-reported memory worsening were assessed using logistic regression, and associations between insomnia and cognitive performance were assessed via linear mixed-effects modeling, adjusted for demographic, lifestyle, and medical factors. An increased odds (OR 1.70; 95% CI 1.29-2.26) of self-reported memory worsening was observed for NIS participants at baseline who developed PID at follow-up compared to those who developed ISO or remained NIS. Additionally, participants whose sleep worsened from baseline to follow-up (i.e. transitioned from NIS to ISO, ISO to PID, or NIS to PID) displayed increased odds (OR 1.22; 95% CI 1.10-1.34) of subjective memory worsening at follow-up compared to those who remained insomnia-free or improved their sleep. There were no significant associations between the development of PID or worsening sleep and performance on neuropsychological tests. These findings of an increased odds for subjective memory decline in middle-aged and older adults with insomnia disorder suggest insomnia may be an important target for early interventions addressing age-related cognitive decline.
Identifiants
pubmed: 35877203
pii: 6649765
doi: 10.1093/sleep/zsac176
pmc: PMC9644124
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : CIHR
ID : FDN154291
Pays : Canada
Organisme : CIHR
ID : MOP 142191
Pays : Canada
Organisme : CIHR
ID : LSA 94473
Pays : Canada
Organisme : CIHR
ID : PJT 153115
Pays : Canada
Organisme : CIHR
ID : PJT 156125
Pays : Canada
Organisme : CIHR
ID : PJT 166167
Pays : Canada
Organisme : CIHR
ID : PJT-153259
Pays : Canada
Commentaires et corrections
Type : CommentIn
Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of Sleep Research Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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