Elevated Plasma Phosphorylated Tau 181 in Amyotrophic Lateral Sclerosis.


Journal

Annals of neurology
ISSN: 1531-8249
Titre abrégé: Ann Neurol
Pays: United States
ID NLM: 7707449

Informations de publication

Date de publication:
11 2022
Historique:
revised: 21 07 2022
received: 06 04 2022
accepted: 23 07 2022
pubmed: 26 7 2022
medline: 26 10 2022
entrez: 25 7 2022
Statut: ppublish

Résumé

Plasma phosphorylated tau (p-tau Patients were clinically or pathologically diagnosed with ALS (n = 130) or AD (n = 79), or were healthy non-impaired controls (n = 26). Receiver operating characteristic (ROC) curves were analyzed and area under the curve (AUC) was used to discriminate AD from ALS. Within ALS, Mann-Whitney-Wilcoxon tests compared analytes by presence/absence of upper motor neuron and lower motor neuron (LMN) signs. Spearman correlations tested associations between plasma p-tau A Wilcoxon test showed plasma p-tau We found strong evidence that plasma p-tau

Identifiants

pubmed: 35877814
doi: 10.1002/ana.26462
pmc: PMC9588516
mid: NIHMS1825841
doi:

Substances chimiques

tau Proteins 0
Biomarkers 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

807-818

Subventions

Organisme : NINDS NIH HHS
ID : K23 NS114167
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG052943
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG066597
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS115139
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG062418
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072979
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG054519
Pays : United States

Informations de copyright

© 2022 American Neurological Association.

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Auteurs

Katheryn A Q Cousins (KAQ)

Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Leslie M Shaw (LM)

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA.

Sanjana Shellikeri (S)

Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Laynie Dratch (L)

Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Luis Rosario (L)

Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Lauren B Elman (LB)

Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Colin Quinn (C)

Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Defne A Amado (DA)

Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

David A Wolk (DA)

Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Thomas F Tropea (TF)

Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Alice Chen-Plotkin (A)

Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

David J Irwin (DJ)

Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Murray Grossman (M)

Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Edward B Lee (EB)

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA.

John Q Trojanowski (JQ)

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA.

Corey T McMillan (CT)

Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

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Classifications MeSH