Role of the locus coeruleus and basal forebrain in arousal and attention.
Acetylcholine
GABA
Norepinephrine
Parvalbumin
Vigilance
Wakefulness
Journal
Brain research bulletin
ISSN: 1873-2747
Titre abrégé: Brain Res Bull
Pays: United States
ID NLM: 7605818
Informations de publication
Date de publication:
01 10 2022
01 10 2022
Historique:
received:
14
03
2022
revised:
11
07
2022
accepted:
20
07
2022
pubmed:
26
7
2022
medline:
3
9
2022
entrez:
25
7
2022
Statut:
ppublish
Résumé
Experimental evidence has implicated multiple neurotransmitter systems in either the direct or indirect modulation of cortical arousal and attention circuitry. In this review, we selectively focus on three such systems: 1) norepinephrine (NE)-containing neurons of the locus coeruleus (LC), 2) acetylcholine (ACh)-containing neurons of the basal forebrain (BF), and 3) parvalbumin (PV)-containing gamma-aminobutyric acid neurons of the BF. Whereas BF-PV neurons serve as a rapid and transient arousal system, LC-NE and BF-ACh neuromodulation are typically activated on slower but longer-lasting timescales. Recent findings suggest that the BF-PV system serves to rapidly respond to even subtle sensory stimuli with a microarousal. We posit that salient sensory stimuli, such as those that are threatening or predict the need for a response, will quickly activate the BF-PV system and subsequently activate both the BF-ACh and LC-NE systems if the circumstances require longer periods of arousal and vigilance. We suggest that NE and ACh have overlapping psychological functions with the main difference being the precise internal/environmental sensory situations/contexts that recruit each neurotransmitter system - a goal for future research to determine. Implications of dysfunction of each of these three attentional systems for our understanding of neuropsychiatric conditions are considered. Finally, the contemporary availability of research tools to selectively manipulate and measure the activity of these distinctive neuronal populations promises to answer longstanding questions, such as how various arousal systems influence downstream decision-making and motor responding.
Identifiants
pubmed: 35878679
pii: S0361-9230(22)00178-2
doi: 10.1016/j.brainresbull.2022.07.014
pmc: PMC9514025
mid: NIHMS1836107
pii:
doi:
Substances chimiques
Parvalbumins
0
Acetylcholine
N9YNS0M02X
Norepinephrine
X4W3ENH1CV
Types de publication
Journal Article
Review
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
47-58Subventions
Organisme : NHLBI NIH HHS
ID : T32 HL007901
Pays : United States
Organisme : NIA NIH HHS
ID : K99 AG066819
Pays : United States
Organisme : NIMH NIH HHS
ID : F32 MH119838
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL095491
Pays : United States
Organisme : BLRD VA
ID : IK2 BX002130
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG062421
Pays : United States
Organisme : BLRD VA
ID : I01 BX001356
Pays : United States
Organisme : BLRD VA
ID : I01 BX002774
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH125242
Pays : United States
Organisme : BLRD VA
ID : I01 BX004500
Pays : United States
Organisme : BLRD VA
ID : IK6 BX005714
Pays : United States
Informations de copyright
Published by Elsevier Inc.
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