Development of a new preclinical model to study early implant loss: a validation study in the beagle dog.
Animal model
Early implant loss
Infection
Journal
Clinical oral investigations
ISSN: 1436-3771
Titre abrégé: Clin Oral Investig
Pays: Germany
ID NLM: 9707115
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
received:
13
01
2022
accepted:
12
07
2022
pubmed:
27
7
2022
medline:
11
11
2022
entrez:
26
7
2022
Statut:
ppublish
Résumé
To develop a new preclinical model to study early implant loss, where local infection conditions would impair the implant osseointegration. Forty-eight smooth, 2.9-mm diameter experimental implants were placed in the mandible of 8 beagle dogs (3 in each side). In half of the animals (test group, n = 24 implants), the implants received ligatures around the implant-abutment connection. In the other half, no ligatures were placed (control group, n = 24 implants). Four weeks later, implants were extracted in a flapless approach and standard 3.3-mm diameter SLActive implants were placed into the same osteotomy site without any further drilling. Eight weeks after the second implantation, animals were sacrificed and analyzed in terms of implant survival. After 8 weeks of healing, 4 implants were lost in the control group and 14 in the test group. This corresponded to a 17.4% of early implant loss in the control group and 58.3% in the test. Most of the early failures occurred within the first 5 weeks of healing. Implants placed in a pre-contaminated site present higher early loss than those placed in a non-contaminated site. This study represents a valid and robust preclinical model to study mechanisms and reduction of early implant loss as new technologies become available. Scientific rationale for the study: There is lack of animal models to study early implant loss. Thus, a proposal of a new model is presented. With the validation of this model, new technologies can be implemented to prevent early implant loss.
Identifiants
pubmed: 35882681
doi: 10.1007/s00784-022-04642-3
pii: 10.1007/s00784-022-04642-3
pmc: PMC9643266
doi:
Substances chimiques
Dental Implants
0
Types de publication
Journal Article
Langues
eng
Pagination
6805-6815Subventions
Organisme : International Team for Implantology
ID : 1111_2015
Informations de copyright
© 2022. The Author(s).
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