Taurine and N-Bromotaurine in Topical Treatment of Psoriasis.
N-bromotaurine
Olive oil
Sulfur metabolism
Taurine
Topical psoriasis treatment
Journal
Advances in experimental medicine and biology
ISSN: 0065-2598
Titre abrégé: Adv Exp Med Biol
Pays: United States
ID NLM: 0121103
Informations de publication
Date de publication:
2022
2022
Historique:
entrez:
26
7
2022
pubmed:
27
7
2022
medline:
29
7
2022
Statut:
ppublish
Résumé
Psoriasis is a chronic skin auto-inflammatory and systemic disorder. Novel treatments are needed to solve a plethora of cases refractory to current treatment regimens. N-bromotaurine (TauNH-Br), a natural taurine oxidizing derivative produced by inflammatory cells, has anti-inflammatory, antiproliferative, and antimicrobial properties. This evidence prompted us to use TauNH-Br as a local agent for treatment of therapy-refractory psoriasis. Two pustular-plaque psoriasis cases, unresponsive to systemic and local treatments, one with localized lesions and one with generalized lesions, were selected. Both applications primarily indicated a sufficient curative activity of 1% TauNH-Br in psoriasis lesions. Moreover, TauNH-Br co-administration with taurine and a novel olive oil formulation cut in half the time needed for TauNH-Br alone to cause the same regression of equivalent psoriasis plaque lesions in the same patient. Importantly, all adverse effects of TauNH-Br (erythema, itching, bleeding) could be minimized by the combination therapy. Periods of 2-7 weeks to achieve almost complete regression with this formulation were remarkably short as compared to conventional treatment regimens that both patients had followed previously. Of note, there was no relapse within 3 months of monitoring. Combination formulations containing TauNH-Br and olive oil could become an advantageous topical medication for treatment of psoriasis.
Identifiants
pubmed: 35882785
doi: 10.1007/978-3-030-93337-1_9
doi:
Substances chimiques
Olive Oil
0
Taurine
1EQV5MLY3D
N-bromotaurine
52316-57-1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
99-111Informations de copyright
© 2022. The Author(s), under exclusive license to Springer Nature Switzerland AG.
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