Heterocycle-Based Multicomponent Reactions in Drug Discovery: From Hit Finding to Rational Design.
bioprobes
drug discovery
heterocycles
multicomponent reactions
reaction discovery
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
23 Jun 2022
23 Jun 2022
Historique:
received:
31
05
2022
revised:
16
06
2022
accepted:
20
06
2022
entrez:
27
7
2022
pubmed:
28
7
2022
medline:
28
7
2022
Statut:
epublish
Résumé
In the context of the structural complexity necessary for a molecule to selectively display a therapeutical action and the requirements for suitable pharmacokinetics, a robust synthetic approach is essential. Typically, thousands of relatively similar compounds should be prepared along the drug discovery process. In this respect, heterocycle-based multicomponent reactions offer advantages over traditional stepwise sequences in terms of synthetic economy, as well as the fast access to chemsets to study the structure activity relationships, the fine tuning of properties, and the preparation of larger amounts for preclinical phases. In this account, we briefly summarize the scientific methodology backing the research line followed by the group. We comment on the main results, clustered according to the targets and, finally, in the conclusion section, we offer a general appraisal of the situation and some perspectives regarding future directions in academic and private research.
Identifiants
pubmed: 35884794
pii: biomedicines10071488
doi: 10.3390/biomedicines10071488
pmc: PMC9313418
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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