ATR Contributes More Than ATM in Intra-S-Phase Checkpoint Activation after IR, and DNA-PKcs Facilitates Recovery: Evidence for Modular Integration of ATM/ATR/DNA-PKcs Functions.
ATM
ATR
DNA Double Strand Breaks (DSB)
DNA-PK
DSB end resection (resection)
intra-S-phase checkpoint
ionizing radiation (IR)
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
06 Jul 2022
06 Jul 2022
Historique:
received:
30
05
2022
revised:
24
06
2022
accepted:
04
07
2022
entrez:
27
7
2022
pubmed:
28
7
2022
medline:
29
7
2022
Statut:
epublish
Résumé
The intra-S-phase checkpoint was among the first reported cell cycle checkpoints in mammalian cells. It transiently slows down the rate of DNA replication after DNA damage to facilitate repair and thus prevents genomic instability. The ionizing radiation (IR)-induced intra-S-phase checkpoint in mammalian cells is thought to be mainly dependent upon the kinase activity of ATM. Defects in the intra-S-phase checkpoint result in radio-resistant DNA synthesis (RDS), which promotes genomic instability. ATM belongs to the PI3K kinase family along with ATR and DNA-PKcs. ATR has been shown to be the key kinase for intra-S-phase checkpoint signaling in yeast and has also been implicated in this checkpoint in higher eukaryotes. Recently, contributions of DNA-PKcs to IR-induced G
Identifiants
pubmed: 35886852
pii: ijms23147506
doi: 10.3390/ijms23147506
pmc: PMC9316047
pii:
doi:
Substances chimiques
Cell Cycle Proteins
0
DNA
9007-49-2
ATM protein, human
EC 2.7.11.1
ATR protein, human
EC 2.7.11.1
Ataxia Telangiectasia Mutated Proteins
EC 2.7.11.1
Checkpoint Kinase 1
EC 2.7.11.1
DNA-Activated Protein Kinase
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Federal Ministry of Education and Research
ID : 02NUK037B, 02NUK043B, 02NUK054B
Organisme : Deutsche Forschungsgemeinschaft
ID : GRK1739
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