Low Doses of PFOA Promote Prostate and Breast Cancer Cells Growth through Different Pathways.
PFOA
endocrine disrupting chemicals
hormone-dependent cancers
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
18 Jul 2022
18 Jul 2022
Historique:
received:
29
06
2022
revised:
12
07
2022
accepted:
14
07
2022
entrez:
27
7
2022
pubmed:
28
7
2022
medline:
29
7
2022
Statut:
epublish
Résumé
Endocrine Disrupting Compounds (EDCs) are found in everyday products. Widely distributed throughout the environment, persistent organic pollutants (POPs) are a specific class of EDCs that can accumulate in adipose tissue. Many of them induce adverse effects on human health-such as obesity, fertility disorders and cancers-by perturbing hormone effects. We previously identified many compounds with EDC activity in the circulation of obese patients who underwent bariatric surgery. Herein, we analyzed the effects of four of them (aldrin, BDE28, PFOA and PCB153) on two cancer cell lines of hormone-sensitive organs (prostate and breast). Each cell line was exposed to serial dilutions of EDCs from 10
Identifiants
pubmed: 35887249
pii: ijms23147900
doi: 10.3390/ijms23147900
pmc: PMC9318902
pii:
doi:
Substances chimiques
Endocrine Disruptors
0
Hormones
0
Aldrin
OZE3CLY605
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : French Agency for Food, Environmental and Occupational Health & Safety
ID : EST-17-086
Organisme : the French government, through the UCAJEDI Investments in the Future project managed by the National Research Agency (ANR)
ID : ANR-15-IDEX-01 (ProstAdiPE Project, Academy #3)
Organisme : ITMO
ID : Plan Cancer 2014-2019
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