A Novel Dimeric Conotoxin, FrXXA, from the Vermivorous Cone Snail
Conus fergusoni
Conus snails
alpha d-conotoxin
dimeric-peptides
nAChR
Journal
Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765
Informations de publication
Date de publication:
26 07 2022
26 07 2022
Historique:
received:
23
06
2022
revised:
05
07
2022
accepted:
10
07
2022
entrez:
27
7
2022
pubmed:
28
7
2022
medline:
29
7
2022
Statut:
epublish
Résumé
We isolated a new dimeric conotoxin with inhibitory activity against neuronal nicotinic acetylcholine receptors. Edman degradation and transcriptomic studies indicate a homodimeric conotoxin composed by two chains of 47 amino acid in length. It has the cysteine framework XX and 10 disulfide bonds. According to conotoxin nomenclature, it has been named as αD-FrXXA. The αD-FrXXA conotoxin inhibited the ACh-induced response on nAChR with a IC
Identifiants
pubmed: 35893752
pii: toxins14080510
doi: 10.3390/toxins14080510
pmc: PMC9330476
pii:
doi:
Substances chimiques
Conotoxins
0
Nicotinic Antagonists
0
Receptors, Nicotinic
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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