Genetic polymorphism of HLA-DRA and alcohol consumption affect hepatitis development in the Korean population.
Alcohol consumption
HLA-DRA
Hepatitis
Korean population
Single nucleotide polymorphism
Journal
Genes & genomics
ISSN: 2092-9293
Titre abrégé: Genes Genomics
Pays: Korea (South)
ID NLM: 101481027
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
received:
25
12
2021
accepted:
10
07
2022
pubmed:
28
7
2022
medline:
23
8
2022
entrez:
27
7
2022
Statut:
ppublish
Résumé
Hepatitis is an inflammation of the liver that has several potential causes; however, the genetic association has recently begun to be studied. Human leukocyte antigen (HLA) is an essential component of the immune response, and in this study, we conducted a correlation analysis to determine whether genetic polymorphisms of HLA and drinking habits affect hepatitis development. Genetic polymorphisms of HLA were investigated using Korean genomic and epidemiological data. A gene association study was performed using PLINK version 1.07. Other statistical analyses and multivariate logistic regression analyses were performed using PASW Statistics version 18.0. Thirteen single nucleotide polymorphisms (SNPs) in HLA-DRA showed significant statistical correlations with hepatitis. In particular, rs9268645 showed the highest statistical association with hepatitis (P = 3.97 × 10 Our results showed that hepatitis is influenced by both genetic and external factors (drinking habits), which can provide new guidelines for the prevention or treatment of hepatitis.
Sections du résumé
BACKGROUND
Hepatitis is an inflammation of the liver that has several potential causes; however, the genetic association has recently begun to be studied.
OBJECTIVES
Human leukocyte antigen (HLA) is an essential component of the immune response, and in this study, we conducted a correlation analysis to determine whether genetic polymorphisms of HLA and drinking habits affect hepatitis development.
METHODS
Genetic polymorphisms of HLA were investigated using Korean genomic and epidemiological data. A gene association study was performed using PLINK version 1.07. Other statistical analyses and multivariate logistic regression analyses were performed using PASW Statistics version 18.0.
RESULTS
Thirteen single nucleotide polymorphisms (SNPs) in HLA-DRA showed significant statistical correlations with hepatitis. In particular, rs9268645 showed the highest statistical association with hepatitis (P = 3.97 × 10
CONCLUSIONS
Our results showed that hepatitis is influenced by both genetic and external factors (drinking habits), which can provide new guidelines for the prevention or treatment of hepatitis.
Identifiants
pubmed: 35895219
doi: 10.1007/s13258-022-01286-1
pii: 10.1007/s13258-022-01286-1
doi:
Substances chimiques
HLA-DR alpha-Chains
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1109-1116Informations de copyright
© 2022. The Author(s) under exclusive licence to The Genetics Society of Korea.
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