Functional Versatility of the Human 2-Oxoadipate Dehydrogenase in the L-Lysine Degradation Pathway toward Its Non-Cognate Substrate 2-Oxopimelic Acid.

2-oxoadipate dehydrogenase 2-oxoadipate dehydrogenase complex 2-oxopimelate substrate E1a promiscuity H2O2 production L-lysine degradation pathway rare E1a variants

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
26 Jul 2022
Historique:
received: 23 06 2022
revised: 23 07 2022
accepted: 24 07 2022
entrez: 28 7 2022
pubmed: 29 7 2022
medline: 30 7 2022
Statut: epublish

Résumé

The human 2-oxoadipate dehydrogenase complex (OADHc) in L-lysine catabolism is involved in the oxidative decarboxylation of 2-oxoadipate (OA) to glutaryl-CoA and NADH (+H

Identifiants

pubmed: 35897808
pii: ijms23158213
doi: 10.3390/ijms23158213
pmc: PMC9367764
pii:
doi:

Substances chimiques

NAD 0U46U6E8UK
DHTKD1 protein, human EC 1.2.4.2
Ketoglutarate Dehydrogenase Complex EC 1.2.4.2
Lysine K3Z4F929H6

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NICHD NIH HHS
ID : R03 HD092878
Pays : United States
Organisme : NIH HHS
ID : GM050380, R15-GM116077
Pays : United States
Organisme : Hungarian Brain Research program 2
ID : 2017-1.2.1-NKP-2017-00002
Organisme : Semmelweis University
ID : STIA-OTKA-2021, TKP2021-EGA-25, TKP2021-EGA-25
Organisme : NICHD NIH HHS
ID : R21 HD088775
Pays : United States
Organisme : Eunice Kennedy Shriver National Institute of Child Health and Human Development
ID : R03HD092878, R21HD088775

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Auteurs

Natalia S Nemeria (NS)

Department of Chemistry, Rutgers University-Newark, Newark, NJ 07102-1811, USA.

Balint Nagy (B)

Department of Biochemistry, Institute of Biochemistry and Molecular Biology, Semmelweis University, 1082 Budapest, Hungary.

Roberto Sanchez (R)

Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6501, USA.

Xu Zhang (X)

Department of Chemistry, Rutgers University-Newark, Newark, NJ 07102-1811, USA.

João Leandro (J)

Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6501, USA.

Attila Ambrus (A)

Department of Biochemistry, Institute of Biochemistry and Molecular Biology, Semmelweis University, 1082 Budapest, Hungary.

Sander M Houten (SM)

Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6501, USA.

Frank Jordan (F)

Department of Chemistry, Rutgers University-Newark, Newark, NJ 07102-1811, USA.

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Classifications MeSH