The sphingolipid anteome: implications for evolution of the sphingolipid metabolic pathway.
Darwinian evolution
last universal common ancestor
membrane
metabolic evolution
metabolism
origin of life
sphingolipids
Journal
FEBS letters
ISSN: 1873-3468
Titre abrégé: FEBS Lett
Pays: England
ID NLM: 0155157
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
revised:
10
07
2022
received:
16
06
2022
accepted:
19
07
2022
pubmed:
29
7
2022
medline:
28
9
2022
entrez:
28
7
2022
Statut:
ppublish
Résumé
Modern cell membranes contain a bewildering complexity of lipids, among them sphingolipids (SLs). Advances in mass spectrometry have led to the realization that the number and combinatorial complexity of lipids, including SLs, is much greater than previously appreciated. SLs are generated de novo by four enzymes, namely serine palmitoyltransferase, 3-ketodihydrosphingosine reductase, ceramide synthase and dihydroceramide Δ4-desaturase 1. Some of these enzymes depend on the availability of specific substrates and cofactors, which are themselves supplied by other complex metabolic pathways. The evolution of these four enzymes is poorly understood and likely depends on the co-evolution of the metabolic pathways that supply the other essential reaction components. Here, we introduce the concept of the 'anteome', from the Latin ante ('before') to describe the network of metabolic ('omic') pathways that must have converged in order for these pathways to co-evolve and permit SL synthesis. We also suggest that the current origin of life and evolutionary models lack appropriate experimental support to explain the appearance of this complex metabolic pathway and its anteome.
Identifiants
pubmed: 35899376
doi: 10.1002/1873-3468.14457
doi:
Substances chimiques
Ceramides
0
Sphingolipids
0
Fatty Acid Desaturases
EC 1.14.19.-
Serine C-Palmitoyltransferase
EC 2.3.1.50
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2345-2363Informations de copyright
© 2022 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
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