Minimal invasiveness in the reconstructive treatment of peri-implantitis defects.
biomaterials
bone substitutes
defect fill
dental implants
peri-implantitis
surgical treatment
Journal
Periodontology 2000
ISSN: 1600-0757
Titre abrégé: Periodontol 2000
Pays: Denmark
ID NLM: 9313276
Informations de publication
Date de publication:
02 2023
02 2023
Historique:
revised:
30
05
2022
received:
16
04
2022
accepted:
05
06
2022
medline:
11
5
2023
pubmed:
29
7
2022
entrez:
28
7
2022
Statut:
ppublish
Résumé
Peri-implantitis is a plaque-associated pathologic condition occurring in tissues around dental implants, clinically characterized by increased peri-implant probing pocket depth and progressive loss of supporting bone. Consequently, to arrest further disease progression and to increase the chance to obtain re-osseointegration, surgical reconstructive procedures have been adopted. In particular, following a paradigm gathered from periodontal therapy, recent protocols have underlined the importance of a minimally invasive approach to optimize the outcomes of therapy while minimizing the risks of postoperative complications. The present review summarizes the level of evidence on the surgical reconstructive protocols focusing on the new approaches aiming to minimize surgical trauma and patients' postoperative discomfort, underlining the pros and cons of each treatment modality.
Substances chimiques
Dental Implants
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
199-216Informations de copyright
© 2022 The Authors. Periodontology 2000 published by John Wiley & Sons Ltd.
Références
Berglundh T, Armitage G, Araujo MG, et al. Peri-implant diseases and conditions: consensus report of workgroup 4 of the 2017 world workshop on the classification of periodontal and peri-implant diseases and conditions. J Periodontol. 2018;89(Suppl 1):S313-S318.
Figuero E, Graziani F, Sanz I, Herrera D, Sanz M. Management of peri-implant mucositis and peri-implantitis. Periodontol 2000. 2014;66(1):255-273.
Suarez-Lopez Del Amo F, Yu SH, Wang HL. Non-surgical therapy for peri-implant diseases: a systematic review. J Oral Maxillofac Res. 2016;7(3):e13.
Roccuzzo, A., Klossner, S., Stähli, A., Imber, J. C., Eick, S., Sculean, A., Salvi, G. E. (2022). Non-surgical mechanical therapy of peri-implantitis with or without repeated adjunctive diode laser application. A 6-month double-blinded randomized clinical trial. Clinical Oral Implants Research. doi: 10.1111/clr.13969 [Online ahead of print]
Berglundh T, Wennstrom JL, Lindhe J. Long-term outcome of surgical treatment of peri-implantitis. A 2-11-year retrospective study. Clin Oral Implants Res. 2018;29(4):404-410.
Gonzalez Regueiro I, Martinez Rodriguez N, Barona Dorado C, et al. Surgical approach combining implantoplasty and reconstructive therapy with locally delivered antibiotic in the treatment of peri-implantitis: a prospective clinical case series. Clin Implant Dent Relat Res. 2021;23(6):864-873.
Schwarz F, Herten M, Sager M, Bieling K, Sculean A, Becker J. Comparison of naturally occurring and ligature-induced peri-implantitis bone defects in humans and dogs. Clin Oral Implants Res. 2007;18(2):161-170.
Schwarz F, John G, Schmucker A, Sahm N, Becker J. Combined surgical therapy of advanced peri-implantitis evaluating two methods of surface decontamination: a 7-year follow-up observation. J Clin Periodontol. 2017;44(3):337-342.
Tomasi C, Regidor E, Ortiz-Vigon A, Derks J. Efficacy of reconstructive surgical therapy at peri-implantitis-related bone defects. A systematic review and meta-analysis. J Clin Periodontol. 2019;46(Suppl 21):340-356.
Tsitoura E, Tucker R, Suvan J, Laurell L, Cortellini P, Tonetti M. Baseline radiographic defect angle of the intrabony defect as a prognostic indicator in regenerative periodontal surgery with enamel matrix derivative. J Clin Periodontol. 2004;31(8):643-647.
Cortellini P, Pini-Prato G, Nieri M, Tonetti MS. Minimally invasive surgical technique and enamel matrix derivative in intrabony defects: 2. Factors associated with healing outcomes. Int J Periodontics Restorative Dent. 2009;29(3):257-265.
Cortellini P, Tonetti MS. Clinical and radiographic outcomes of the modified minimally invasive surgical technique with and without regenerative materials: a randomized-controlled trial in intra-bony defects. J Clin Periodontol. 2011;38(4):365-373.
Sanz M, Tonetti MS, Zabalegui I, et al. Treatment of intrabony defects with enamel matrix proteins or barrier membranes: results from a multicenter practice-based clinical trial. J Periodontol. 2004;75(5):726-733.
Jepsen S, Heinz B, Jepsen K, et al. A randomized clinical trial comparing enamel matrix derivative and membrane treatment of buccal class II furcation involvement in mandibular molars. Part I: study design and results for primary outcomes. J Periodontol. 2004;75(8):1150-1160.
Polymeri A, Anssari-Moin D, van der Horst J, Wismeijer D, Laine ML, Loos BG. Surgical treatment of peri-implantitis defects with two different xenograft granules: a randomized clinical pilot study. Clin Oral Implants Res. 2020;31(11):1047-1060.
Astolfi V, Gomez-Menchero A, Rios-Santos JV, et al. Influence of removing or leaving the prosthesis after regenerative surgery in peri-implant defects: retrospective study: 32 clinical cases with 2 to 8 years of follow-up. Int J Environ Res Public Health. 2021;18(2):645.
Takei HH, Han TJ, Carranza FA Jr, Kenney EB, Lekovic V. Flap technique for periodontal bone implants. Papilla Preservation Technique. J Periodontol. 1985;56(4):204-210.
Cortellini P, Prato GP, Tonetti MS. The modified papilla preservation technique. a new surgical approach for interproximal regenerative procedures. J Periodontol. 1995;66(4):261-266.
Cortellini P, Prato GP, Tonetti MS. The simplified papilla preservation flap. A novel surgical approach for the management of soft tissues in regenerative procedures. Int J Periodontics Restorative Dent. 1999;19(6):589-599.
Sanz-Martin I, Cha JK, Sanz-Sanchez I, Figuero E, Herrera D, Sanz M. Changes in peri-implant soft tissue levels following surgical treatment of peri-implantitis: a systematic review and meta-analysis. Clin Oral Implants Res. 2021;32(Suppl 21):230-244.
Renvert S, Polyzois I, Maguire R. Re-osseointegration on previously contaminated surfaces: a systematic review. Clin Oral Implants Res. 2009;20(Suppl 4):216-227.
Carcuac O, Berglundh T. Composition of human peri-implantitis and periodontitis lesions. J Dent Res. 2014;93(11):1083-1088.
Monje A, Blasi G. Significance of keratinized mucosa/gingiva on peri-implant and adjacent periodontal conditions in erratic maintenance compliers. J Periodontol. 2019;90(5):445-453.
Monje A, Pons R, Insua A, Nart J, Wang HL, Schwarz F. Morphology and severity of peri-implantitis bone defects. Clin Implant Dent Relat Res. 2019;21(4):635-643.
Wehner C, Bertl K, Durstberger G, Arnhart C, Rausch-Fan X, Stavropoulos A. Characteristics and frequency distribution of bone defect configurations in peri-implantitis lesions-a series of 193 cases. Clin Implant Dent Relat Res. 2021;23(2):178-188.
Iorio-Siciliano V, Gasparro R, Blasi A, et al. Treatment of a peri-implantitis defect using a mini-invasive surgical approach (MISA) and deproteinized bovine bone mineral with 10% collagen: a case series. J Biol Regul Homeost Agents. 2019;33(6 Suppl. 2):41-47.
Fletcher P, Tarnow DP. Circumferential occlusal access procedure (COAP): novel minimally invasive surgical approach for treatment of peri-Implantitis- acase series. Compend Contin Educ Dent. 2018;39(9):626-635.
Wilson TG Jr. A new minimally invasive approach for treating peri-Implantitis. Clin Adv Periodontics. 2019;9(2):59-63.
Trombelli L, Severi M, Farina R, Simonelli A. Sub-periosteal peri-implant augmented layer technique to treat peri-Implantitis lesions. Clin Adv Periodontics. 2020;10(4):169-174.
Lee J, Choi JU, Lee JB, Dds IR, Lee YM. A case report of a 2-year follow-up of minimally invasive surgery in peri-implantitis: peri-implant excisional procedure and access surgery (PEAS). J Oral Implantol. 2021. doi: 10.1563/aaid-joi-D-20-00344
Cortellini P, Cortellini S, Bonaccini D, Tonetti MS. Papilla preservation and minimally invasive surgery for the treatment of peri-implant osseous defects. Clinical and radiographic outcomes of a 5-year retrospective study. Clin Oral Implants Res. 2021;32(11):1384-1396. doi: 10.1111/clr.13826
Noelken R, Al-Nawas B. A modified surgical approach for hard and soft tissue reconstruction of severe periimplantitis defects: laser-assisted periimplant defect regeneration (LAPIDER). Int J Implant Dent. 2020;6(1):22.
Khoury F, Buchmann R. Surgical therapy of peri-implant disease: a 3-year follow-up study of cases treated with 3 different techniques of bone regeneration. J Periodontol. 2001;72(11):1498-1508.
Berglundh T, Gislason O, Lekholm U, Sennerby L, Lindhe J. Histopathological observations of human periimplantitis lesions. J Clin Periodontol. 2004;31(5):341-347.
Renvert S, Roos-Jansaker AM, Claffey N. Non-surgical treatment of peri-implant mucositis and peri-implantitis: a literature review. J Clin Periodontol. 2008;35(8 Suppl):305-315.
Trombelli L, Severi M, Pramstraller M, Farina R. A simplified soft tissue management for peri-implant bone augmentation. Int J Oral Maxillofac Implants. 2019;34(1):197-204.
Nobuto T, Suwa F, Kono T, et al. Microvascular response in the periosteum following mucoperiosteal flap surgery in dogs: angiogenesis and bone resorption and formation. J Periodontol. 2005;76(8):1346-1353.
Moreno Rodriguez JA, Caffesse RG. Nonincised papillae surgical approach (NIPSA) in periodontal regeneration: preliminary results of a case series. Int J Periodontics Restorative Dent. 2018;38(Suppl):s105-s111.
Moreno Rodriguez JA, Ortiz Ruiz AJ, Zamora GP, Pecci-Lloret M, Caffesse RG. Connective tissue grafts with nonincised papillae surgical approach for periodontal reconstruction in noncontained defects. Int J Periodontics Restorative Dent. 2019;39(6):781-787.
Serino G, Strom C. Peri-implantitis in partially edentulous patients: association with inadequate plaque control. Clin Oral Implants Res. 2009;20(2):169-174.
de Tapia B, Mozas C, Valles C, Nart J, Sanz M, Herrera D. Adjunctive effect of modifying the implant-supported prosthesis in the treatment of peri-implant mucositis. J Clin Periodontol. 2019;46(10):1050-1060.
Needleman I, Tucker R, Giedrys-Leeper E, Worthington H. Guided tissue regeneration for periodontal intrabony defects--a Cochrane Systematic Review. Periodontol 2000. 2005;37:106-123.
Roos-Jansaker AM, Persson GR, Lindahl C, Renvert S. Surgical treatment of peri-implantitis using a bone substitute with or without a resorbable membrane: a 5-year follow-up. J Clin Periodontol. 2014;41(11):1108-1114.
Myeroff C, Archdeacon M. Autogenous bone graft: donor sites and techniques. J Bone Joint Surg Am. 2011;93(23):2227-2236.
Kamal M, Gremse F, Rosenhain S, et al. Comparison of bone grafts from various donor sites in human bone specimens. J Craniofac Surg. 2018;29(6):1661-1665.
Madi M, Htet M, Zakaria O, Alagl A, Kasugai S. Re-osseointegration of dental implants after periimplantitis treatments: asystematic review. Implant Dent. 2018;27(1):101-110.
Hamzacebi B, Oduncuoglu B, Alaaddinoglu EE. Treatment of peri-implant bone defects with platelet-rich fibrin. Int J Periodontics Restorative Dent. 2015;35(3):415-422.
Sun G, Cao L, Li H. Effects of platelet-rich fibrin combined with guided bone regeneration in the reconstruction of peri-implantitis bone defect. Am J Transl Res. 2021;13(7):8397-8402.
Isler SC, Soysal F, Ceyhanlı T, Bakırarar B, Unsal B. Regenerative surgical treatment of peri-implantitis using either a collagen membrane or concentrated growth factor: a 12-month randomized clinical trial. Clin Implant Dent Relat Res. 2018;20(5):703-712.
Duong, H. Y., Roccuzzo, A., Stähli, A., Salvi, G. E., Lang, N. P., Sculean, A. (2022). Oral health-related quality of life of patients rehabilitated with fixed and removable implant-supported dental prostheses. Periodontology 2000, 88(1), 201-237.
Miron RJ, Sculean A, Cochran DL, et al. Twenty years of enamel matrix derivative: the past, the present and the future. J Clin Periodontol. 2016;43(8):668-683.
Maymon-Gil T, Weinberg E, Nemcovsky C, Weinreb M. Enamel matrix derivative promotes healing of a surgical wound in the rat Oral mucosa. J Periodontol. 2016;87(5):601-609.
Froum SJ, Froum SH, Rosen PS. Successful management of peri-implantitis with a regenerative approach: a consecutive series of 51 treated implants with 3- to 7.5-year follow-up. Int J Periodontics Restorative Dent. 2012;32(1):11-20.
Mercado F, Hamlet S, Ivanovski S. Regenerative surgical therapy for peri-implantitis using deproteinized bovine bone mineral with 10% collagen, enamel matrix derivative and doxycycline-a prospective 3-year cohort study. Clin Oral Implants Res. 2018;29(6):583-591.
Isehed C, Holmlund A, Renvert S, Svenson B, Johansson I, Lundberg P. Effectiveness of enamel matrix derivative on the clinical and microbiological outcomes following surgical regenerative treatment of peri-implantitis. A randomized controlled trial. J Clin Periodontol. 2016;43(10):863-873.
Isehed C, Svenson B, Lundberg P, Holmlund A. Surgical treatment of peri-implantitis using enamel matrix derivative, an RCT: 3- and 5-year follow-up. J Clin Periodontol. 2018;45(6):744-753.
Tastepe CS, van Waas R, Liu Y, Wismeijer D. Air powder abrasive treatment as an implant surface cleaning method: a literature review. Int J Oral Maxillofac Implants. 2012;27(6):1461-1473.
Schlee M, Naili L, Rathe F, Brodbeck U, Zipprich H. Is complete re-osseointegration of an infected dental implant possible? Histologic results of a dog study: a short communication. J Clin Med. 2020;9(1):235.
Ratka C, Weigl P, Henrich D, Koch F, Schlee M, Zipprich H. The effect of in vitro electrolytic cleaning on biofilm-contaminated implant surfaces. J Clin Med. 2019;8(9):1397.
Schlee M, Rathe F, Brodbeck U, Ratka C, Weigl P, Zipprich H. Treatment of peri-implantitis-electrolytic cleaning versus mechanical and electrolytic cleaning-arandomized controlled clinical trial-six-month results. J Clin Med. 2019;8(11):1909.
Schlee M, Wang HL, Stumpf T, Brodbeck U, Bosshardt D, Rathe F. Treatment of periimplantitis with electrolytic cleaning versus mechanical and electrolytic cleaning: 18-month results from a randomized controlled clinical trial. J Clin Med. 2021;10(16):3475.
Takasaki AA, Aoki A, Mizutani K, Kikuchi S, Oda S, Ishikawa I. Er:YAG laser therapy for peri-implant infection: a histological study. Lasers Med Sci. 2007;22(3):143-157.
Aoki A, Mizutani K, Schwarz F, et al. Periodontal and peri-implant wound healing following laser therapy. Periodontol 2000. 2015;68(1):217-269.
Wang CW, Ashnagar S, Gianfilippo RD, Arnett M, Kinney J, Wang HL. Laser-assisted regenerative surgical therapy for peri-implantitis: a randomized controlled clinical trial. J Periodontol. 2021;92(3):378-388.
Hauser-Gerspach I, Stubinger S, Meyer J. Bactericidal effects of different laser systems on bacteria adhered to dental implant surfaces: an in vitro study comparing zirconia with titanium. Clin Oral Implants Res. 2010;21(3):277-283.
Sanz M, Herrera D, Kebschull M, et al. Treatment of stage I-III periodontitis-the EFP S3 level clinical practice guideline. J Clin Periodontol. 2020;47(Suppl 22):4-60.
Heitz-Mayfield LJA, Salvi GE, Mombelli A, Faddy M, Lang NP. Anti-infective surgical therapy of peri-implantitis. A 12-month prospective clinical study. Clin Oral Implants Res. 2012;23(2):205-210.
Carcuac O, Derks J, Charalampakis G, Abrahamsson I, Wennstrom J, Berglundh T. Adjunctive systemic and local antimicrobial therapy in the surgical treatment of peri-implantitis: arandomized controlled clinical trial. J Dent Res. 2016;95(1):50-57.
Nart J, de Tapia B, Pujol À, Pascual A, Valles C. Vancomycin and tobramycin impregnated mineralized allograft for the surgical regenerative treatment of peri-implantitis: a 1-year follow-up case series. Clin Oral Investig. 2018;22(6):2199-2207.
Nart J, Pons R, Valles C, Esmatges A, Sanz-Martin I, Monje A. Non-surgical therapeutic outcomes of peri-implantitis: 12-month results. Clin Oral Investig. 2020;24(2):675-682.
Blanco C, Pico A, Dopico J, Gandara P, Blanco J, Linares A. Adjunctive benefits of systemic metronidazole on non-surgical treatment of peri-implantitis. A randomized placebo-controlled clinical trial. J Clin Periodontol. 2022;49(1):15-27.
Sukumar S, Martin FE, Hughes TE, Adler CJ. Think before you prescribe: how dentistry contributes to antibiotic resistance. Aust Dent J. 2020;65(1):21-29.
Fraimow HS. Systemic antimicrobial therapy in osteomyelitis. Semin Plast Surg. 2009;23(2):90-99.
Shibli JA, Ferrari DS, Siroma RS, Figueiredo LC, Faveri M, Feres M. Microbiological and clinical effects of adjunctive systemic metronidazole and amoxicillin in the non-surgical treatment of peri-implantitis: 1 year follow-up. Braz Oral Res. 2019;33(suppl 1):e080.
Stein JM, Hammacher C, Michael SS. Combination of ultrasonic decontamination, soft tissue curettage, and submucosal air polishing with povidone-iodine application for non-surgical therapy of peri-implantitis: 12 month clinical outcomes. J Periodontol. 2017;89(2):50-60.
Gaviria L, Salcido JP, Guda T, Ong JL. Current trends in dental implants. J Korean Assoc Oral Maxillofac Surg. 2014;40(2):139-147.
De Ry SP, Roccuzzo A, Lang NP, et al. Evaluation of the implant disease risk assessment (IDRA) tool: a retrospective study in patients with treated periodontitis and implant-supported fixed dental prostheses (FDPs). Clin Oral Implants Res. 2021;32(11):1299-1307.
Etter TH, Hakanson I, Lang NP, Trejo PM, Caffesse RG. Healing after standardized clinical probing of the perlimplant soft tissue seal: a histomorphometric study in dogs. Clin Oral Implants Res. 2002;13(6):571-580.
Jacobs R, Salmon B, Codari M, Hassan B, Bornstein MM. Cone beam computed tomography in implant dentistry: recommendations for clinical use. BMC Oral Health. 2018;18(1):88.
Insua A, Ganan Y, Macias Y, Garcia JA, Rakic M, Monje A. Diagnostic accuracy of cone beam computed tomography in identifying peri-implantitis-like bone defects ex vivo. Int J Periodontics Restorative Dent. 2021;41(6):e223-e231.
Roccuzzo M, Mirra D, Pittoni D, Ramieri G, Roccuzzo A. Reconstructive treatment of peri-implantitis infrabony defects of various configurations: 5-year survival and success. Clin Oral Implants Res. 2021;32:1209-1217.
Monje A, Aranda L, Diaz KT, et al. Impact of maintenance therapy for the prevention of peri-implant diseases: asystematic review and meta-analysis. J Dent Res. 2016;95(4):372-379.
Aghazadeh A, Rutger Persson G, Renvert S. A single-Centre randomized controlled clinical trial on the adjunct treatment of intra-bony defects with autogenous bone or a xenograft: results after 12 months. J Clin Periodontol. 2012;39(7):666-673.
Khoshkam V, Suárez-López Del Amo F, Monje A, Lin GH, Chan HL, Wang HL. Long-term radiographic and clinical outcomes of regenerative approach for treating peri-implantitis: asystematic review and meta-analysis. Int J Oral Maxillofac Implants. 2016;31(6):1303-1310.
Romeo E, Ghisolfi M, Murgolo N, Chiapasco M, Lops D, Vogel G. Therapy of peri-implantitis with resective surgery. A 3-year clinical trial on rough screw-shaped oral implants. Part I: clinical outcome. Clin Oral Implants Res. 2005;16(1):9-18.
Deppe H, Horch HH, Neff A. Conventional versus CO2 laser-assisted treatment of peri-implant defects with the concomitant use of pure-phase beta-tricalcium phosphate: a 5-year clinical report. Int J Oral Maxillofac Implants. 2007;22(1):79-86.
Froum SJ, Froum SH, Rosen PS. A regenerative approach to the successful treatment of peri-implantitis: aconsecutive series of 170 implants in 100 patients with 2- to 10-year follow-up. Int J Periodontics Restorative Dent. 2015;35(6):857-863.
Schwarz F, Hegewald A, John G, Sahm N, Becker J. Four-year follow-up of combined surgical therapy of advanced peri-implantitis evaluating two methods of surface decontamination. J Clin Periodontol. 2013;40(10):962-967.
Solakoglu Ö, Filippi A. Regenerative therapy of peri-Implantitis: clinical and radiologic documentation of 16 consecutive patients with a mean follow-up of 3 years. J Oral Implantol. 2019;45(2):145-153.
Schwarz F, Sahm N, Bieling K, Becker J. Surgical regenerative treatment of peri-implantitis lesions using a nanocrystalline hydroxyapatite or a natural bone mineral in combination with a collagen membrane: a four-year clinical follow-up report. J Clin Periodontol. 2009;36(9):807-814.
Renvert S, Roos-Jansåker AM, Persson GR. Surgical treatment of peri-implantitis lesions with or without the use of a bone substitute-a randomized clinical trial. J Clin Periodontol. 2018;45(10):1266-1274.
Schwarz F, Sahm N, Schwarz K, Becker J. Impact of defect configuration on the clinical outcome following surgical regenerative therapy of peri-implantitis. J Clin Periodontol. 2010;37(5):449-455.
Aghazadeh A, Persson RG, Renvert S. Impact of bone defect morphology on the outcome of reconstructive treatment of peri-implantitis. Int J Implant Dent. 2020;6(1):33.
Perussolo J, Souza AB, Matarazzo F, Oliveira RP, Araujo MG. Influence of the keratinized mucosa on the stability of peri-implant tissues and brushing discomfort: a 4-year follow-up study. Clin Oral Implants Res. 2018;29(12):1177-1185.
Roccuzzo M, Grasso G, Dalmasso P. Keratinized mucosa around implants in partially edentulous posterior mandible: 10-year results of a prospective comparative study. Clin Oral Implants Res. 2016;27(4):491-496.
Ravida A, Saleh I, Siqueira R, et al. Influence of keratinized mucosa on the surgical therapeutical outcomes of peri-implantitis. J Clin Periodontol. 2020;47(4):529-539.
Monje A, Blasi G, Nart J, Urban IA, Nevins M, Wang HL. Soft tissue conditioning for the surgical therapy of peri-implantitis: aprospective 12-month study. Int J Periodontics Restorative Dent. 2020;40(6):899-906.
Solonko M, Regidor E, Ortiz-Vigon A, Montero E, Vilchez B, Sanz M. Efficacy of keratinized mucosal augmentation with a collagen matrix concomitant to the surgical treatment of peri-implantitis: a dual-center randomized clinical trial. Clin Oral Implants Res. 2021;33(1):105-119.
Schwarz F, Jepsen S, Herten M, Sager M, Rothamel D, Becker J. Influence of different treatment approaches on non-submerged and submerged healing of ligature induced peri-implantitis lesions: an experimental study in dogs. J Clin Periodontol. 2006;33(8):584-595.
Roos-Jansaker AM, Lindahl C, Persson GR, Renvert S. Long-term stability of surgical bone regenerative procedures of peri-implantitis lesions in a prospective case-control study over 3 years. J Clin Periodontol. 2011;38(6):590-597.
Monje A, Pons R, Roccuzzo A, Salvi GE, Nart J. Reconstructive therapy for the management of peri-implantitis via submerged guided bone regeneration: a prospective case series. Clin Implant Dent Relat Res. 2020;22(3):342-350.
Pons R, Nart J, Valles C, Salvi GE, Monje A. Self-administered proximal implant-supported hygiene measures and the association to peri-implant conditions. J Periodontol. 2021;92(3):389-399.
Wetzel AC, Vlassis J, Caffesse RG, Hammerle CH, Lang NP. Attempts to obtain re-osseointegration following experimental peri-implantitis in dogs. Clin Oral Implants Res. 1999;10(2):111-119.
Shibli JA, Martins MC, Ribeiro FS, Garcia VG, Nociti FH Jr, Marcantonio E Jr. Lethal photosensitization and guided bone regeneration in treatment of peri-implantitis: an experimental study in dogs. Clin Oral Implants Res. 2006;17(3):273-281.
Almohandes A, Carcuac O, Abrahamsson I, Lund H, Berglundh T. Re-osseointegration following reconstructive surgical therapy of experimental peri-implantitis. A pre-clinical in vivo study. Clin Oral Implants Res. 2019;30(5):447-456.
Rodriguez JC, Koticha T, Eubanks DL, et al. Influence of microtextured implant surfaces on peri-implantitis and its treatment: apreclinical trial. Int J Oral Maxillofac Implants. 2018;33(1):51-57.
Roccuzzo M, Pittoni D, Roccuzzo A, Charrier L, Dalmasso P. Surgical treatment of peri-implantitis intrabony lesions by means of deproteinized bovine bone mineral with 10% collagen: 7-year-results. Clin Oral Implants Res. 2017;28(12):1577-1583.
Roccuzzo M, Fierravanti L, Pittoni D, Dalmasso P, Roccuzzo A. Implant survival after surgical treatment of peri-implantitis lesions by means of deproteinized bovine bone mineral with 10% collagen: 10-year results from a prospective study. Clin Oral Implants Res. 2020;31(8):768-776.
La Monaca G, Pranno N, Annibali S, Cristalli MP, Polimeni A. Clinical and radiographic outcomes of a surgical reconstructive approach in the treatment of peri-implantitis lesions: a 5-year prospective case series. Clin Oral Implants Res. 2018;29(10):1025-1037.
Roccuzzo M, Layton DM, Roccuzzo A, Heitz-Mayfield LJ. Clinical outcomes of peri-implantitis treatment and supportive care: a systematic review. Clin Oral Implants Res. 2018;29(Suppl 16):331-350.
Menini M, Delucchi F, Bagnasco F, Pera F, Di Tullio N, Pesce P. Efficacy of air-polishing devices without removal of implant-supported full-arch prostheses. Int J Oral Implantol (Berl). 2021;14(4):401-416.