Role of B-Cell in the Pathogenesis of Systemic Sclerosis.
B-cell
B-cell receptor (BCR)
autoantibodies
interleukine 6 (IL-6)
pathogenesis
rituximab
systemic sclerosis
transcriptomic
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
30
04
2022
accepted:
06
06
2022
entrez:
29
7
2022
pubmed:
30
7
2022
medline:
2
8
2022
Statut:
epublish
Résumé
Systemic sclerosis (SSc) is a rare multisystem autoimmune disease, characterized by fibrosis, vasculopathy, and autoimmunity. Recent advances have highlighted the significant implications of B-cells in SSc. B-cells are present in affected organs, their subpopulations are disrupted, and they display an activated phenotype, and the regulatory capacities of B-cells are impaired, as illustrated by the decrease in the IL-10+ producing B-cell subpopulation or the inhibitory membrane co-receptor density. Recent multi-omics evidence highlights the role of B-cells mainly in the early stage of SSc and preferentially during severe organ involvement. This dysregulated homeostasis partly explains the synthesis of anti-endothelial cell autoantibodies (AECAs) or anti-fibroblast autoantibodies (AFAs), proinflammatory or profibrotic cytokines (interleukin-6 and transforming growth factor-β) produced by B and plasma cells. That is associated with cell-to-cell interactions with endothelial cells, fibroblasts, vascular smooth muscle cells, and other immune cells, altogether leading to cell activation and proliferation, cell resistance to apoptosis, the impairment of regulatory mechanisms, and causing fibrosis of several organs encountered in the SSc. Finally, alongside these exploratory data, treatments targeting B-cells, through their depletion by cytotoxicity (anti-CD20 monoclonal antibody), or the cytokines produced by the B-cell, or their costimulation molecules, seem interesting, probably in certain profiles of early patients with severe organic damage.
Identifiants
pubmed: 35903091
doi: 10.3389/fimmu.2022.933468
pmc: PMC9315392
doi:
Substances chimiques
Autoantibodies
0
Cytokines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
933468Informations de copyright
Copyright © 2022 Thoreau, Chaigne and Mouthon.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Rheumatol. 2007 Oct;34(10):2056-62
pubmed: 17896803
Arthritis Rheumatol. 2018 Dec;70(12):2087-2095
pubmed: 29956883
Mol Immunol. 2004 Jul;41(6-7):599-613
pubmed: 15219998
Lancet. 2016 Jun 25;387(10038):2630-2640
pubmed: 27156934
Cytokine Growth Factor Rev. 2013 Jun;24(3):203-15
pubmed: 23684423
Rheumatology (Oxford). 2012 Sep;51(9):1540-9
pubmed: 22577083
Arthritis Rheumatol. 2018 Mar;70(3):450-461
pubmed: 29193892
Rheumatology (Oxford). 2021 Feb 1;60(2):557-567
pubmed: 33164098
Arthritis Res Ther. 2016 Jun 07;18(1):131
pubmed: 27267753
Presse Med. 2021 Apr;50(1):104087
pubmed: 34718115
Nat Rev Rheumatol. 2021 Oct;17(10):596-607
pubmed: 34480165
Arthritis Rheum. 2004 Jun;50(6):1918-27
pubmed: 15188368
Rheumatol Int. 2018 Jul;38(7):1225-1234
pubmed: 29869007
N Engl J Med. 2018 Jan 4;378(1):35-47
pubmed: 29298160
Rheumatology (Oxford). 2016 Feb;55(2):263-7
pubmed: 26350483
Arthritis Res Ther. 2016 May 21;18(1):118
pubmed: 27208972
Rheumatology (Oxford). 2018 Dec 1;57(12):2106-2113
pubmed: 30053212
Cells. 2020 Dec 07;9(12):
pubmed: 33297481
Arthritis Rheum. 2006 Mar;54(3):963-73
pubmed: 16508979
Front Immunol. 2017 Feb 07;8:53
pubmed: 28223983
Am J Respir Crit Care Med. 2008 May 15;177(10):1128-34
pubmed: 18276943
Clin Exp Rheumatol. 2016 Sep-Oct;34 Suppl 100(5):30-36
pubmed: 27056741
Int J Rheum Dis. 2013 Apr;16(2):148-56
pubmed: 23639027
N Engl J Med. 2006 Jun 22;354(25):2667-76
pubmed: 16790699
Nat Commun. 2014 Jun 09;5:4092
pubmed: 24910129
Arthritis Rheum. 1977 May;20(4):975-84
pubmed: 861067
Arthritis Res Ther. 2017 Jan 19;19(1):8
pubmed: 28103916
J Clin Invest. 2015 Jul 1;125(7):2795-807
pubmed: 26098215
Ann Rheum Dis. 2019 Apr;78(4):539-550
pubmed: 30760472
JCI Insight. 2018 May 3;3(9):
pubmed: 29720568
Eur J Med Res. 2010 Jan 29;15(1):44-6
pubmed: 20159671
JAMA. 2014 Jun 25;311(24):2490-8
pubmed: 25058083
Arthritis Rheum. 2007 Jan;56(1):334-44
pubmed: 17195237
Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12319-24
pubmed: 14530402
Rheumatology (Oxford). 2003 Apr;42(4):534-40
pubmed: 12649400
RMD Open. 2017 Jul 28;3(2):e000384
pubmed: 28879049
Gastroenterology. 2002 Oct;123(4):1144-50
pubmed: 12360477
Inflammation. 2012 Jun;35(3):810-7
pubmed: 21882074
Ann Rheum Dis. 2020 Mar;79(3):379-386
pubmed: 31767698
Blood. 2011 Jan 13;117(2):530-41
pubmed: 20962324
Rheumatology (Oxford). 2022 Feb 02;:
pubmed: 35108379
Ann Rheum Dis. 2009 May;68(5):710-4
pubmed: 18762475
Arthritis Rheum. 2008 Sep;58(9):2866-73
pubmed: 18759276
Immunol Lett. 2018 Mar;195:55-60
pubmed: 28987475
Arthritis Res Ther. 2018 Mar 22;20(1):52
pubmed: 29566745
Arthritis Rheum. 2010 Feb;62(2):589-98
pubmed: 20112391
Rheumatology (Oxford). 2021 Dec 1;60(12):5538-5548
pubmed: 33724344
Arthritis Res Ther. 2014 Jan 28;16(1):R29
pubmed: 24472528
Arthritis Rheumatol. 2018 Feb;70(2):308-316
pubmed: 29073351
J Exp Med. 1997 Feb 3;185(3):461-9
pubmed: 9053446
Arthritis Res Ther. 2019 Apr 29;21(1):106
pubmed: 31036055
Autoimmun Rev. 2018 Mar;17(3):244-255
pubmed: 29343447
Autoimmunity. 2013 Nov;46(7):463-70
pubmed: 24083390
Arthritis Rheumatol. 2019 Sep;71(9):1553-1570
pubmed: 30969034
Front Immunol. 2018 Jul 23;9:1702
pubmed: 30083163
Arthritis Rheumatol. 2016 Feb;68(2):494-504
pubmed: 26414243
Nat Immunol. 2001 Sep;2(9):764-6
pubmed: 11526379
J Rheumatol. 1998 Feb;25(2):308-13
pubmed: 9489824
Genes Immun. 2009 Apr;10(3):210-8
pubmed: 19129850
Sci Transl Med. 2018 Mar 7;10(431):
pubmed: 29514998
Arthritis Rheum. 2000 Nov;43(11):2550-62
pubmed: 11083280
Clin Genet. 2017 Oct;92(4):365-371
pubmed: 27918067
Clin Rev Allergy Immunol. 2020 Feb;58(1):40-51
pubmed: 30607749
Clin Exp Immunol. 2020 Sep;201(3):233-243
pubmed: 32538493
Front Immunol. 2015 Sep 29;6:496
pubmed: 26483788
Rheumatology (Oxford). 2016 Jul;55(7):1318-24
pubmed: 27060110
J Allergy Clin Immunol. 2015 Apr;135(4):946-955.e9
pubmed: 25678090
Clin Exp Rheumatol. 2015 Jul-Aug;33(4 Suppl 91):S15-22
pubmed: 26148346
J Biol Chem. 2014 Apr 4;289(14):9952-60
pubmed: 24550394
Am Rev Respir Dis. 1991 Sep;144(3 Pt 1):706-13
pubmed: 1892314
J Rheumatol. 2018 Mar;45(3):405-410
pubmed: 29093152
Am J Pathol. 2006 Sep;169(3):954-66
pubmed: 16936269
Arthritis Rheum. 2013 Nov;65(11):2737-47
pubmed: 24122180
Arthritis Res Ther. 2012 Jun 14;14(3):R145
pubmed: 22697462
Vascul Pharmacol. 2013 Jul-Aug;59(1-2):19-26
pubmed: 23685129
Arthritis Rheum. 1992 Jan;35(1):95-100
pubmed: 1731817
J Immunol. 1995 Sep 1;155(5):2703-14
pubmed: 7650398
Arthritis Rheum. 2007 Sep;56(9):3167-8
pubmed: 17763433
Arthritis Res Ther. 2013 Oct 28;15(5):R168
pubmed: 24289101
Am J Respir Crit Care Med. 2021 Jul 15;204(2):209-221
pubmed: 33651671
Clin Exp Immunol. 2010 Feb;159(2):176-84
pubmed: 19919568
Front Immunol. 2017 Feb 08;8:75
pubmed: 28228756
Rheumatology (Oxford). 2017 Aug 1;56(8):1348-1357
pubmed: 28444364
Clin Immunol. 2012 Apr;143(1):39-44
pubmed: 22306512
Arch Dermatol Res. 2010 Jan;302(1):27-35
pubmed: 19844733
Ann Rheum Dis. 2017 Nov;76(11):1897-1905
pubmed: 28835464
J Rheumatol. 2013 Jan;40(1):52-7
pubmed: 23118116
Sci Immunol. 2017 Sep 29;2(15):
pubmed: 28963118
Presse Med. 2021 Apr;50(1):104088
pubmed: 34718109
Thorax. 2005 Sep;60(9):765-72
pubmed: 16135682
Immunity. 2018 Apr 17;48(4):702-715.e4
pubmed: 29669250
Arthritis Rheum. 2006 Jan;54(1):192-201
pubmed: 16385515
J Rheumatol. 2015 Oct;42(10):1801-7
pubmed: 26233500
Blood Adv. 2018 Jan 23;2(2):126-141
pubmed: 29365321
J Clin Invest. 2002 Jun;109(11):1453-62
pubmed: 12045259
Arthritis Res Ther. 2018 Apr 18;20(1):75
pubmed: 29669578
Lancet. 2011 Aug 6;378(9790):498-506
pubmed: 21777972
J Invest Dermatol. 2007 Dec;127(12):2772-80
pubmed: 17581616
PLoS One. 2009 Jun 17;4(6):e5903
pubmed: 19536281
Sci Adv. 2018 Jul 11;4(7):eaas9944
pubmed: 30009261
J Rheumatol. 1992 Aug;19(8):1207-11
pubmed: 1404155
Blood. 2015 Jun 25;125(26):4085-94
pubmed: 25852057
J Dermatol Sci. 2014 Jun;74(3):214-21
pubmed: 24679982
Arthritis Rheumatol. 2017 May;69(5):1078-1089
pubmed: 27992693
Ann Rheum Dis. 2010 Feb;69(2):428-33
pubmed: 19293162
J Invest Dermatol. 2003 Apr;120(4):542-7
pubmed: 12648215
Autoimmun Rev. 2017 Oct;16(10):1029-1035
pubmed: 28778706
Rheumatology (Oxford). 2012 Mar;51(3):460-7
pubmed: 22087012
Arthritis Rheumatol. 2020 Mar;72(3):465-476
pubmed: 31682743
Curr Opin Rheumatol. 2015 Nov;27(6):537-41
pubmed: 26285102
J Dermatol. 2018 Oct;45(10):1221-1224
pubmed: 30051925
J Immunol. 2000 Dec 1;165(11):6635-43
pubmed: 11086109
Arthritis Res Ther. 2014 Jul 24;16(4):R157
pubmed: 25059342
Ann Rheum Dis. 2019 Oct;78(10):1371-1378
pubmed: 31391177
Eur Respir J. 2006 Oct;28(4):799-807
pubmed: 16774952
Arthritis Rheumatol. 2017 Sep;69(9):1879-1890
pubmed: 28556548
Am J Pathol. 2004 Aug;165(2):641-50
pubmed: 15277237
J Dermatol Sci. 2001 Oct;27(2):140-6
pubmed: 11532378
N Engl J Med. 2014 Jan 30;370(5):433-43
pubmed: 24350901
Ann Rheum Dis. 2012 Apr;71(4):596-605
pubmed: 22084393
Immunol Lett. 2018 Mar;195:83-87
pubmed: 29032187
Arthritis Rheum. 2013 Feb;65(2):481-91
pubmed: 23045159
J Pathol. 1992 Mar;166(3):255-63
pubmed: 1517881
Blood. 2014 Sep 4;124(10):1677-88
pubmed: 25009225
Ann Rheum Dis. 2021 Dec;80(12):1584-1593
pubmed: 34230031
J Rheumatol. 2010 Nov;37(11):2286-9
pubmed: 20810514
Clin Respir J. 2012 Jan;6(1):9-17
pubmed: 21801327
Rheumatology (Oxford). 2010 Dec;49(12):2408-12
pubmed: 20819796
Lancet Respir Med. 2020 Oct;8(10):963-974
pubmed: 32866440
Arthritis Rheum. 1984 Jun;27(6):645-53
pubmed: 6375682
J Immunol. 2000 Jun 15;164(12):6138-46
pubmed: 10843663
Curr Opin Immunol. 2008 Apr;20(2):149-57
pubmed: 18434123
Arthritis Rheum. 2008 Dec;58(12):3913-23
pubmed: 19035500