Development and validation of an LC-ESI-QTOF-MS method to measure cefepime in the plasma and peritoneal fluid of rats using microdialysis: Application in a pilot pharmacokinetic study.
LC-ESI-QTOF-MS
bioanalysis
cefepime
microdialysis
plasma
Journal
Biomedical chromatography : BMC
ISSN: 1099-0801
Titre abrégé: Biomed Chromatogr
Pays: England
ID NLM: 8610241
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
revised:
21
07
2022
received:
11
05
2022
accepted:
25
07
2022
pubmed:
30
7
2022
medline:
5
10
2022
entrez:
29
7
2022
Statut:
ppublish
Résumé
Cefepime (CEF) is a cephalosporin and can be administered in secondary peritonitis together with metronidazole to treat sepsis. This study aimed to develop and validate an LC-ESI-QTOF-MS method for the quantification of cefepime in the plasma and peritoneal microdialysate of healthy Wistar rats. Chromatographic separation was performed using a CLC-ODS C
Substances chimiques
Acetonitriles
0
Water
059QF0KO0R
Metronidazole
140QMO216E
Gallic Acid
632XD903SP
Cefepime
807PW4VQE3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e5470Informations de copyright
© 2022 John Wiley & Sons Ltd.
Références
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