Cerebrospinal fluid findings in adult patients with obsessive-compulsive disorder: A retrospective analysis of 54 samples.

Animals Mice Retrospective Studies Obsessive-Compulsive Disorder / diagnosis Autoantibodies / metabolism Brain / metabolism Immunoglobulin G / metabolism
Cerebrospinal fluid autoantibodies autoimmunity neuroinflammatory diseases obsessive-compulsive disorder

Journal

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
ISSN: 1814-1412
Titre abrégé: World J Biol Psychiatry
Pays: England
ID NLM: 101120023

Informations de publication

Date de publication:
04 2023
Historique:
medline: 3 4 2023
pubmed: 30 7 2022
entrez: 29 7 2022
Statut: ppublish

Résumé

Obsessive-compulsive disorder (OCD) can rarely be associated with immunological aetiologies, most notably in Basic CSF findings of 54 adult OCD patients suspected of an organic aetiology were retrospectively compared to a control group of mentally healthy patients ( Elevated protein in the CSF of OCD patients compared to the control group ( While elevated CSF protein is merely a weak indicator of blood CSF barrier dysfunction, the presence of inflammatory CSF changes and novel brain autoantibodies in CSF may indicate OCD subtypes with inflammatory pathomechanism and supports the hypothesis of a rare "autoimmune OCD" subtype.

Identifiants

DOI: 10.1080/15622975.2022.2104457 PMID: 35904379
pubmed: 35904379
doi: 10.1080/15622975.2022.2104457
doi:

Substances chimiques

Autoantibodies 0
Immunoglobulin G 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

292-302

Auteurs

Benjamin Pankratz (B)

Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Katharina von Zedtwitz (K)

Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Kimon Runge (K)

Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Dominik Denzel (D)

Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Kathrin Nickel (K)

Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Andrea Schlump (A)

Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Karoline Pitsch (K)

Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Simon Maier (S)

Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Rick Dersch (R)

Department of Neurology and Neurophysiology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Ulrich Voderholzer (U)

Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Prien am Chiemsee, Schoen Clinic Roseneck, Prien, Germany.
Department of Psychiatry and Psychotherapy, University Hospital Munich, Munich, Germany.

Katharina Domschke (K)

Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Center for Basics in Neuromodulation, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
ORCID: 0000-0002-2550-9132

Ludger Tebartz van Elst (L)

Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
ORCID: 0000-0002-2274-5447

Miriam A Schiele (MA)

Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
ORCID: 0000-0003-2613-6515

Harald Prüss (H)

Department of Neurology and Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
ORCID: 0000-0002-8283-7976

Dominique Endres (D)

Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
ORCID: 0000-0001-7322-1195

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Cerebrospinal fluid findings in adult patients...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Cerebrospinal fluid findings in adult patients...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Cerebrospinal fluid findings in adult patients...
questionsmedicales.fr › Troubles mentaux › Troubles anxieux › Trouble obsessionnel compulsif › Cerebrospinal fluid findings in adult patients...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Autoanticorps › Cerebrospinal fluid findings in adult patients...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Cerebrospinal fluid findings in adult patients...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Isotypes des immunoglobulines › Immunoglobuline G › Cerebrospinal fluid findings in adult patients...