Differential Frequencies of Intermediate Monocyte Subsets Among Individuals Infected With Drug-Sensitive or Drug-Resistant
TB immune responses
drug-resistant TB (DR-TB)
immunophenotyping
monocyte to lymphocyte ratio
monocytes and dendritic cell subsets
neutrophil to lymphocyte ratio
uniform manifold approximation and projection (UMAP)
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
09
03
2022
accepted:
21
06
2022
entrez:
1
8
2022
pubmed:
2
8
2022
medline:
3
8
2022
Statut:
epublish
Résumé
The rampant increase in drug-resistant tuberculosis (TB) remains a major challenge not only for treatment management but also for diagnosis, as well as drug design and development. Drug-resistant mycobacteria affect the quality of life owing to the delayed diagnosis and require prolonged treatment with multiple and toxic drugs. The phenotypic modulations defining the immune status of an individual during tuberculosis are well established. The present study aims to explore the phenotypic changes of monocytes & dendritic cells (DC) as well as their subsets across the TB disease spectrum, from latency to drug-sensitive TB (DS-TB) and drug-resistant TB (DR-TB) using traditional immunophenotypic analysis and by uniform manifold approximation and projection (UMAP) analysis. Our results demonstrate changes in frequencies of monocytes (classical, CD14
Identifiants
pubmed: 35911760
doi: 10.3389/fimmu.2022.892701
pmc: PMC9336531
doi:
Substances chimiques
HLA-DR Antigens
0
Interleukin-3 Receptor alpha Subunit
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
892701Informations de copyright
Copyright © 2022 Sampath, Natarajan, Moideen, Kathamuthu, Hissar, Dhanapal, Jayabal, Ramesh, Tripathy, Ranganathan, Babu and Bethunaickan.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Eur Respir J. 2022 Apr 21;59(4):
pubmed: 34711538
Eur J Immunol. 2013 Feb;43(2):327-30
pubmed: 23322255
Open Forum Infect Dis. 2019 May 31;6(7):ofz257
pubmed: 31281858
Nat Rev Immunol. 2014 Aug;14(8):571-8
pubmed: 25033907
Cell Res. 2015 Dec;25(12):1333-51
pubmed: 26482950
Blood. 2010 Oct 21;116(16):e74-80
pubmed: 20628149
Nat Rev Microbiol. 2004 Mar;2(3):189-202
pubmed: 15083155
Annu Rev Immunol. 2000;18:767-811
pubmed: 10837075
Diseases. 2018 Dec 23;7(1):
pubmed: 30583589
Front Immunol. 2018 Jul 30;9:1726
pubmed: 30105020
EBioMedicine. 2015 Nov;2(11):1619-26
pubmed: 26870787
World J Gastroenterol. 2016 Jan 28;22(4):1393-404
pubmed: 26819508
J Infect. 2015 Apr;70(4):346-55
pubmed: 25452040
Curr Opin Immunol. 2008 Aug;20(4):371-6
pubmed: 18602003
Nat Rev Immunol. 2017 Jan;17(1):21-29
pubmed: 27916977
Tuberculosis (Edinb). 2016 Dec;101:191-200
pubmed: 27865391
Mol Immunol. 2017 Nov;91:86-96
pubmed: 28889065
PLoS One. 2017 Feb 16;12(2):e0171358
pubmed: 28208160
Clin Immunol. 2002 Dec;105(3):296-303
pubmed: 12498811
PLoS One. 2018 Mar 15;13(3):e0192664
pubmed: 29543810
Tuberculosis (Edinb). 2011 Sep;91(5):348-60
pubmed: 21621464
Clin Exp Immunol. 1999 Jan;115(1):110-3
pubmed: 9933428
J Transl Med. 2018 Jul 20;16(1):206
pubmed: 30029650
Annu Rev Immunol. 2013;31:563-604
pubmed: 23516985
J Mol Med (Berl). 2007 Jun;85(6):613-21
pubmed: 17318616
Braz J Infect Dis. 2015 Mar-Apr;19(2):125-31
pubmed: 25529365
Microbes Infect. 2007 Nov-Dec;9(14-15):1671-9
pubmed: 18023233
Clujul Med. 2015;88(2):164-7
pubmed: 26528066
Microbes Infect. 2006 Aug;8(9-10):2492-500
pubmed: 16872859
Eur J Immunol. 2013 Feb;43(2):335-47
pubmed: 23192690
Clin Sci (Lond). 2015 Aug;129(4):319-30
pubmed: 25858460
Eur Respir J. 2015 Oct;46(4):1095-103
pubmed: 26250497
Clin Infect Dis. 2000 Jun;30 Suppl 3:S279-82
pubmed: 10875800
J Immunol. 2017 Apr 1;198(7):2834-2843
pubmed: 28193827
J Leukoc Biol. 2018 May;103(5):945-954
pubmed: 29489031
Blood. 2011 Aug 4;118(5):e16-31
pubmed: 21653326
Nature. 2002 Dec 5;420(6915):502-7
pubmed: 12466842
Front Immunol. 2014 Apr 01;5:131
pubmed: 24744755
Clin Exp Immunol. 2006 Feb;143(2):329-37
pubmed: 16412058