Antibody dual-functionalisation enabled through a modular divinylpyrimidine disulfide rebridging strategy.
Journal
Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838
Informations de publication
Date de publication:
18 Aug 2022
18 Aug 2022
Historique:
pubmed:
2
8
2022
medline:
23
8
2022
entrez:
1
8
2022
Statut:
epublish
Résumé
Herein we report the development of a methodology for the dual-functionalisation of IgG antibodies. This is accomplished through the combination of disulfide rebridging divinylpyrimidine technology, with bicyclononyne and methylcyclopropene handles to facilitate sequential SPAAC and IEDDA reactions. Advantageously, the strategy does not require metal catalysis and avoids the need for purification between functionalisation steps.
Identifiants
pubmed: 35912884
doi: 10.1039/d2cc02515a
pmc: PMC9387566
doi:
Substances chimiques
Disulfides
0
Immunoglobulin G
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
9401-9404Références
Nat Commun. 2021 Jun 10;12(1):3528
pubmed: 34112795
Org Biomol Chem. 2016 Jul 14;14(26):6165-78
pubmed: 27278999
Bioconjug Chem. 2019 Oct 16;30(10):2539-2543
pubmed: 31560523
Bioconjug Chem. 2021 Feb 17;32(2):301-310
pubmed: 33476135
Chem Commun (Camb). 2022 Feb 8;58(12):1962-1965
pubmed: 35044383
Mol Cancer Ther. 2017 Jan;16(1):116-123
pubmed: 28062707
Chembiochem. 2019 Sep 16;20(18):2411-2419
pubmed: 31044494
Bioconjug Chem. 2019 Jun 19;30(6):1702-1710
pubmed: 31083974
Chem Soc Rev. 2021 Jan 21;50(2):1305-1353
pubmed: 33290462
Angew Chem Int Ed Engl. 2017 Jan 16;56(3):733-737
pubmed: 27966822
Angew Chem Int Ed Engl. 2018 Mar 5;57(11):2831-2834
pubmed: 29356244
J Am Chem Soc. 2011 Nov 9;133(44):17993-8001
pubmed: 21970470
Angew Chem Int Ed Engl. 2014 Feb 17;53(8):2245-9
pubmed: 24474648
Bioconjug Chem. 2019 Sep 18;30(9):2452-2457
pubmed: 31409067
Angew Chem Int Ed Engl. 2021 Jun 14;60(25):13757-13777
pubmed: 33258535
Nat Commun. 2015 Mar 31;6:6645
pubmed: 25824906
Bioconjug Chem. 2019 Apr 17;30(4):1048-1054
pubmed: 30855134
Bioconjug Chem. 2015 Nov 18;26(11):2249-60
pubmed: 26332743
Free Radic Biol Med. 1990;9(4):315-25
pubmed: 2283087
Chem Sci. 2018 Nov 9;10(3):694-700
pubmed: 30774870
Org Biomol Chem. 2020 Jun 10;18(22):4224-4230
pubmed: 32432632