Inflammasomes as mediators of inflammation in HIV-1 infection.
Journal
Translational research : the journal of laboratory and clinical medicine
ISSN: 1878-1810
Titre abrégé: Transl Res
Pays: United States
ID NLM: 101280339
Informations de publication
Date de publication:
02 2023
02 2023
Historique:
received:
02
06
2022
revised:
23
07
2022
accepted:
27
07
2022
pmc-release:
01
02
2024
pubmed:
3
8
2022
medline:
14
1
2023
entrez:
2
8
2022
Statut:
ppublish
Résumé
Human immunodeficiency virus type 1 (HIV-1) infection is a chronic disease without a known cure. The advent of effective antiretroviral therapy (ART) has enabled people with HIV (PWH) to have significantly prolonged life expectancies. As a result, morbidity and mortality associated with HIV-1 infection have declined considerably. However, these individuals experience chronic systemic inflammation whose multifaceted etiology is associated with other numerous comorbidities. Inflammasomes are vital mediators that contribute to inflammatory signaling in HIV-1 infection. Here, we provide an overview of the inflammatory pathway that underlies HIV-1 infection, explicitly highlighting the role of the NLRP3 inflammasome. We also delineate the current literature on inflammasomes and the therapeutic targeting strategies aimed at the NLRP3 inflammasome to moderate HIV-1 infection-associated inflammation. Here we describe the NLRP3 inflammasome as a key pathway in developing novel therapeutic targets to block HIV-1 replication and HIV-1-associated inflammatory signaling. Controlling the inflammatory pathways is critical in alleviating the morbidities and mortality associated with chronic HIV-1 infection in PWH.
Identifiants
pubmed: 35917903
pii: S1931-5244(22)00173-6
doi: 10.1016/j.trsl.2022.07.008
pmc: PMC10160852
mid: NIHMS1895879
pii:
doi:
Substances chimiques
Inflammasomes
0
NLR Family, Pyrin Domain-Containing 3 Protein
0
Inflammation Mediators
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-8Subventions
Organisme : NIAID NIH HHS
ID : K08 AI120806
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA052255
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA054526
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI152833
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
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