A non-canonical vitamin K cycle is a potent ferroptosis suppressor.

Antidotes / pharmacology Antioxidants / metabolism Carbon-Carbon Ligases / metabolism Coenzymes / metabolism Ferroptosis / drug effects Hydroquinones / metabolism Lipid Peroxidation / drug effects Oxidation-Reduction S100 Calcium-Binding Protein A4 / metabolism Vitamin K / metabolism Warfarin / adverse effects

Journal

Nature

ISSN: 1476-4687

Titre abrégé: Nature

Pays: England

ID NLM: 0410462

Informations de publication

Date de publication:
08 2022

Historique:

received: 01 10 2021

accepted: 23 06 2022

pubmed: 4 8 2022

medline: 27 8 2022

entrez: 3 8 2022

Statut: ppublish

Résumé

Ferroptosis, a non-apoptotic form of cell death marked by iron-dependent lipid peroxidation

Identifiants

DOI: 10.1038/s41586-022-05022-3 PMID: 35922516 PMC: PMC9402432

pubmed: 35922516

doi: 10.1038/s41586-022-05022-3

pii: 10.1038/s41586-022-05022-3

pmc: PMC9402432

doi:

Substances chimiques

Antidotes 0

Antioxidants 0

Coenzymes 0

Hydroquinones 0

S100 Calcium-Binding Protein A4 0

Vitamin K 12001-79-5

Warfarin 5Q7ZVV76EI

Carbon-Carbon Ligases EC 6.4.-

glutamyl carboxylase EC 6.4.-

hydroquinone XV74C1N1AE

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

778-783

Subventions

Organisme : European Research Council

Pays : International

Commentaires et corrections

Type : CommentIn

Informations de copyright

Références

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