Biomarkers Predictive of Distant Disease-free Survival Derived from Diffusion-weighted Imaging of Breast Cancer.
breast neoplasms
diffusion-weighted magnetic resonance imaging
intravoxel incoherent motion
kurtosis
prognosis
Journal
Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine
ISSN: 1880-2206
Titre abrégé: Magn Reson Med Sci
Pays: Japan
ID NLM: 101153368
Informations de publication
Date de publication:
01 Oct 2023
01 Oct 2023
Historique:
medline:
9
10
2023
pubmed:
5
8
2022
entrez:
4
8
2022
Statut:
ppublish
Résumé
To investigate whether intravoxel incoherent motion (IVIM) and/or non-Gaussian diffusion parameters are associated with distant disease-free survival (DDFS) in patients with invasive breast cancer. From May 2013 to March 2015, 101 patients (mean age 60.0, range 28-88) with invasive breast cancer were evaluated prospectively. IVIM parameters (flowing blood volume fraction [f The median observation period was 80 months (range, 35-92 months). Among the 101 patients, 12 (11.9%) developed distant metastasis, with a median time to metastasis of 79 months (range, 10-92 months). Kaplan-Meier analysis showed that DDFS was significantly shorter in patients with K > 0.98 than in those with K ≤ 0.98 (P = 0.04). Cox regression analysis showed a marginal statistical association between K and distant metastasis-free survival (P = 0.05). Non-Gaussian diffusion may be associated with prognosis in invasive breast cancer. A higher K may be a marker to help identify patients at an elevated risk of distant metastasis, which could guide subsequent treatment.
Identifiants
pubmed: 35922924
doi: 10.2463/mrms.mp.2022-0060
pmc: PMC10552669
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
469-476Références
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