Shaping Hox gene activity to generate morphological diversity across vertebrate phylogeny.
fin to limb transition
homeobox genes
tail bud extension
Journal
Essays in biochemistry
ISSN: 1744-1358
Titre abrégé: Essays Biochem
Pays: England
ID NLM: 0043306
Informations de publication
Date de publication:
08 12 2022
08 12 2022
Historique:
received:
27
05
2022
revised:
20
07
2022
accepted:
25
07
2022
pubmed:
5
8
2022
medline:
15
12
2022
entrez:
4
8
2022
Statut:
ppublish
Résumé
The importance of Hox genes for the development and evolution of the vertebrate axial skeleton and paired appendages has been recognized for already several decades. The steady growth of genomic sequence data from an increasing number of vertebrate species, together with the improvement of methods to analyze genomic structure and interactions, as well as to control gene activity in various species has refined our understanding of Hox gene activity in development and evolution. Here, I will review recent data addressing the influence of Hox regulatory processes in the evolution of the fins and the emergence of the tetrapod limb. In addition, I will discuss the involvement of posterior Hox genes in the control of vertebrate axial extension, focusing on an apparently divergent activity that Hox13 paralog group genes have on the regulation of tail bud development in mouse and zebrafish embryos.
Identifiants
pubmed: 35924372
pii: 231623
doi: 10.1042/EBC20220050
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
717-726Informations de copyright
© 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.