TREM2 Promotes Immune Evasion by Mycobacterium tuberculosis in Human Macrophages.
IFN
Mycobacterium tuberculosis
TREM2
macrophage cell death
phagocytosis
reactive oxygen species
triggering receptor expressed on myeloid cells
type I interferon
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
30 08 2022
30 08 2022
Historique:
pubmed:
5
8
2022
medline:
3
9
2022
entrez:
4
8
2022
Statut:
ppublish
Résumé
Macrophage surface receptors are critical for pathogen defense, as they are the gatekeepers for pathogen entry and sensing, which trigger robust immune responses. TREM2 (triggering receptor expressed on myeloid cells 2) is a transmembrane surface receptor that mediates anti-inflammatory immune signaling. A recent study showed that TREM2 is a receptor for mycolic acids in the mycobacterial cell wall and inhibits macrophage activation. However, the underlying functional mechanism of how TREM2 regulates the macrophage antimycobacterial response remains unclear. Here, we show that Mycobacterium tuberculosis, the causative agent for tuberculosis, specifically binds to human TREM2 to disable the macrophage antibacterial response. Live but not killed mycobacteria specifically trigger the upregulation of TREM2 during macrophage infection through a mechanism dependent on STING (the stimulator of interferon genes). TREM2 facilitated uptake of
Identifiants
pubmed: 35924849
doi: 10.1128/mbio.01456-22
pmc: PMC9426521
doi:
Substances chimiques
Cytokines
0
Membrane Glycoproteins
0
Reactive Oxygen Species
0
Receptors, Immunologic
0
TREM2 protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0145622Subventions
Organisme : CIHR
ID : PJT-162424
Pays : Canada
Références
Cell Host Microbe. 2016 Jun 8;19(6):760-9
pubmed: 27281568
J Exp Med. 2005 Feb 21;201(4):647-57
pubmed: 15728241
J Clin Immunol. 2010 Sep;30(5):628-31
pubmed: 20589420
PLoS Pathog. 2014 Jun 12;10(6):e1004167
pubmed: 24945405
Immunobiology. 2008;213(9-10):701-13
pubmed: 18926286
Curr Issues Mol Biol. 2016;20:47-54
pubmed: 26738206
J Res Med Sci. 2018 Jul 26;23:63
pubmed: 30181745
Clin Chem. 2009 Apr;55(4):611-22
pubmed: 19246619
Cell Microbiol. 2013 Sep;15(9):1484-95
pubmed: 23795683
Front Microbiol. 2021 Jan 22;11:613963
pubmed: 33552025
Genes Dev. 2018 Mar 1;32(5-6):327-340
pubmed: 29593066
J Biol Chem. 2013 Aug 23;288(34):24956-71
pubmed: 23846686
J Immunol. 1993 Apr 1;150(7):2920-30
pubmed: 8454864
PLoS Pathog. 2020 May 13;16(5):e1008543
pubmed: 32401783
Infect Immun. 2008 Jun;76(6):2439-47
pubmed: 18391000
Cell. 2015 Mar 12;160(6):1061-71
pubmed: 25728668
Nat Rev Immunol. 2003 Jun;3(6):445-53
pubmed: 12776204
PLoS Pathog. 2010 Dec 16;6(12):e1001230
pubmed: 21187903
J Cell Biol. 2009 Jan 26;184(2):215-23
pubmed: 19171755
Scand J Immunol. 2014 Mar;79(3):187-96
pubmed: 24383713
Sci Rep. 2017 Feb 08;7:42101
pubmed: 28176854
J Exp Med. 2016 May 2;213(5):667-75
pubmed: 27091843
PLoS Pathog. 2013;9(7):e1003499
pubmed: 23874203
Curr Opin Immunol. 2000 Feb;12(1):64-76
pubmed: 10679404
J Neurochem. 2009 Jul;110(1):284-94
pubmed: 19457124
Nat Commun. 2021 Apr 16;12(1):2299
pubmed: 33863908
J Exp Med. 2003 Jan 6;197(1):7-17
pubmed: 12515809
Microb Pathog. 2005 Sep;39(3):57-67
pubmed: 16084683
Sci Transl Med. 2011 Oct 12;3(104):104ra102
pubmed: 21998409
Front Immunol. 2020 Sep 30;11:565924
pubmed: 33101286
Front Immunol. 2021 Oct 20;12:742370
pubmed: 34745115
Mol Med Rep. 2013 Mar;7(3):921-6
pubmed: 23314916
Toxicol In Vitro. 2013 Mar;27(2):954-63
pubmed: 23357416
J Immunol. 2006 Sep 15;177(6):3520-4
pubmed: 16951310
Nat Immunol. 2007 Jun;8(6):610-8
pubmed: 17486091
Immunol Rev. 2021 May;301(1):62-83
pubmed: 33565103
PLoS Med. 2007 Apr;4(4):e124
pubmed: 17425404
PLoS Pathog. 2009 Jun;5(6):e1000474
pubmed: 19521507
Mol Neurodegener. 2018 Dec 20;13(1):66
pubmed: 30572908
Cell Chem Biol. 2022 Jul 21;29(7):1126-1139.e12
pubmed: 35320734
Nature. 2014 Jan 9;505(7482):218-22
pubmed: 24336213
PLoS Pathog. 2010 Apr 22;6(4):e1000864
pubmed: 20421951
Adv Microb Physiol. 2012;60:263-324
pubmed: 22633061
J Immunol. 2010 Jul 15;185(2):929-42
pubmed: 20554962
PLoS One. 2013 Jun 28;8(6):e66326
pubmed: 23840441
J Exp Med. 2005 Oct 3;202(7):987-99
pubmed: 16203868
Front Immunol. 2020 Sep 25;11:559342
pubmed: 33101276
Comp Immunol Microbiol Infect Dis. 2019 Dec;67:101355
pubmed: 31586851
J Neurosci. 2015 Feb 25;35(8):3384-96
pubmed: 25716838
J Leukoc Biol. 2004 Feb;75(2):163-89
pubmed: 14525967
BMC Microbiol. 2016 Oct 28;16(1):251
pubmed: 27793104
J Exp Med. 2018 Nov 5;215(11):2919-2935
pubmed: 30337468
Cell Rep. 2021 Jun 1;35(9):109195
pubmed: 34077724
Microbes Infect. 2000 Mar;2(3):313-6
pubmed: 10758408
Eur J Immunol. 2007 May;37(5):1290-301
pubmed: 17407101
Cell Host Microbe. 2008 Apr 17;3(4):224-32
pubmed: 18407066
Antioxid Redox Signal. 2015 Aug 10;23(5):358-74
pubmed: 26135714
Nat Commun. 2020 May 8;11(1):2270
pubmed: 32385301
Cell. 2012 Jan 20;148(1-2):213-27
pubmed: 22265413
Nat Immunol. 2006 Dec;7(12):1266-73
pubmed: 17110943
Front Microbiol. 2019 Aug 20;10:1922
pubmed: 31481950
Brain Behav Immun. 2019 Oct;81:495-508
pubmed: 31283973
PLoS One. 2010 May 24;5(5):e10777
pubmed: 20520722
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
J Exp Med. 2009 Dec 21;206(13):2879-88
pubmed: 20008526
Am J Respir Cell Mol Biol. 2021 Aug;65(2):176-188
pubmed: 33848212
Proc Natl Acad Sci U S A. 2001 May 8;98(10):5752-7
pubmed: 11320211
J Immunol. 2008 Oct 15;181(8):5545-50
pubmed: 18832712
J Immunol. 2003 Jul 15;171(2):594-9
pubmed: 12847223
J Clin Immunol. 2015 Jan;35(1):1-10
pubmed: 25312698
Am J Respir Crit Care Med. 2013 Jul 15;188(2):201-12
pubmed: 23721075
Front Cell Neurosci. 2019 Oct 10;13:457
pubmed: 31649511
J Neurosci. 2017 Feb 15;37(7):1772-1784
pubmed: 28077724
Oncotarget. 2016 Mar 29;7(13):15394-409
pubmed: 27004401
J Exp Med. 2020 Sep 7;217(9):
pubmed: 32579671
mBio. 2016 Apr 05;7(2):e00342-16
pubmed: 27048801
Cell Host Microbe. 2017 Oct 11;22(4):519-530.e3
pubmed: 29024644
Cell Host Microbe. 2015 Jun 10;17(6):811-819
pubmed: 26048136