The effect of oral medications on fMRI brain activation: A randomized, double blind, controlled pilot trial of older women with overactive bladder.
Anticholinergic
Beta agonist
Cognition
Incontinence
Memory
Overactive bladder
Journal
International urogynecology journal
ISSN: 1433-3023
Titre abrégé: Int Urogynecol J
Pays: England
ID NLM: 101567041
Informations de publication
Date de publication:
05 2023
05 2023
Historique:
received:
20
05
2022
accepted:
29
06
2022
medline:
10
5
2023
pubmed:
5
8
2022
entrez:
4
8
2022
Statut:
ppublish
Résumé
Observational studies have associated oral anticholinergic medications for overactive bladder (OAB) with cognitive impairment. This is the first pilot trial to compare the effects of two classes of OAB medications on brain activity in women. We evaluated the effect of anticholinergic versus non-anticholinergic (Non-Ach) interventions on regional brain activation during a cognitive task. Twelve cognitively normal women seeking OAB therapy were recruited to a randomized, double-blind, parallel, controlled pilot trial. Whole-brain regional activity at baseline and 29 ± 1 days postintervention was assessed with functional magnetic resonance imaging during a working memory task. Average activation strength by region was compared after anticholinergic, beta-3 agonist, or placebo. Two-way ANOVA compared effects of group and time on average activation strength in anticholinergic versus Non-Ach (beta-3 agonists or placebo) groups. The mean (SD) age and body mass index of 12 women were 61 (7) years and 36 (7) kg/m Activation strength in brain regions underlying working memory was lower over time, and recognition scores improved. A powered trial is needed to adequately evaluate for differential effects of OAB oral medications on regional brain activation.
Identifiants
pubmed: 35925203
doi: 10.1007/s00192-022-05300-8
pii: 10.1007/s00192-022-05300-8
pmc: PMC9362589
doi:
Substances chimiques
Cholinergic Antagonists
0
Types de publication
Randomized Controlled Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1035-1042Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2022. The International Urogynecological Association.
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