Elimination of senescent cells inhibits epithelial-mesenchymal transition of retinal pigment epithelial cells.

Cellular Senescence Culture Media, Conditioned / pharmacology Dasatinib / pharmacology Epithelial Cells / metabolism Epithelial-Mesenchymal Transition Humans Hydrogen Peroxide / metabolism Macular Degeneration / metabolism Quercetin / pharmacology Retinal Pigment Epithelium / metabolism Retinal Pigments / metabolism Transforming Growth Factor beta / metabolism
Age-related macular degeneration Epithelial-mesenchymal transition Retinal pigment epithelium Senescence

Journal

Experimental eye research
ISSN: 1096-0007
Titre abrégé: Exp Eye Res
Pays: England
ID NLM: 0370707

Informations de publication

Date de publication:
10 2022
Historique:
received: 13 05 2022
revised: 25 07 2022
accepted: 27 07 2022
pubmed: 5 8 2022
medline: 30 9 2022
entrez: 4 8 2022
Statut: ppublish

Résumé

Age-related macular degeneration (AMD) is one of the most common leading causes of irreversible blindness, and there is no effective treatment for it. It has been reported that aging is the greatest risk factor for AMD, and epithelial-mesenchymal transition (EMT) of retinal pigment epithelium (RPE) cells plays an important role in the pathogenesis of AMD. To clarify the relationship between senescence and EMT in RPE cells, we used the replicative senescence model, H

Identifiants

DOI: 10.1016/j.exer.2022.109207 PMID: 35926646
pubmed: 35926646
pii: S0014-4835(22)00287-1
doi: 10.1016/j.exer.2022.109207
pii:
doi:

Substances chimiques

Culture Media, Conditioned 0
Retinal Pigments 0
Transforming Growth Factor beta 0
Quercetin 9IKM0I5T1E
Hydrogen Peroxide BBX060AN9V
Dasatinib RBZ1571X5H

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

109207

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declarations of interest None.

Auteurs

Furong Gao (F)

Department of Ophthalmology of Tongji Hospital and Laboratory of Clinical and Visual Sciences of Tongji Eye Institute, Tongji University School of Medicine, 389 Xincun Road Shanghai, 200065, China; Department of Biochemistry and Molecular Biology, Tongji University School of Medicine, Shanghai, 200092, China. Electronic address: frgao@tongji.edu.cn.

Lei Wang (L)

Department of Biochemistry and Molecular Biology, Tongji University School of Medicine, Shanghai, 200092, China.

Binxin Wu (B)

Department of Ophthalmology of Tongji Hospital and Laboratory of Clinical and Visual Sciences of Tongji Eye Institute, Tongji University School of Medicine, 389 Xincun Road Shanghai, 200065, China; Department of Biochemistry and Molecular Biology, Tongji University School of Medicine, Shanghai, 200092, China.

Qingjian Ou (Q)

Department of Ophthalmology of Tongji Hospital and Laboratory of Clinical and Visual Sciences of Tongji Eye Institute, Tongji University School of Medicine, 389 Xincun Road Shanghai, 200065, China.

Haibin Tian (H)

Department of Ophthalmology of Tongji Hospital and Laboratory of Clinical and Visual Sciences of Tongji Eye Institute, Tongji University School of Medicine, 389 Xincun Road Shanghai, 200065, China; Department of Biochemistry and Molecular Biology, Tongji University School of Medicine, Shanghai, 200092, China.

Jingying Xu (J)

Department of Ophthalmology of Tongji Hospital and Laboratory of Clinical and Visual Sciences of Tongji Eye Institute, Tongji University School of Medicine, 389 Xincun Road Shanghai, 200065, China.

Caixia Jin (C)

Department of Ophthalmology of Tongji Hospital and Laboratory of Clinical and Visual Sciences of Tongji Eye Institute, Tongji University School of Medicine, 389 Xincun Road Shanghai, 200065, China; Department of Biochemistry and Molecular Biology, Tongji University School of Medicine, Shanghai, 200092, China.

Jieping Zhang (J)

Department of Ophthalmology of Tongji Hospital and Laboratory of Clinical and Visual Sciences of Tongji Eye Institute, Tongji University School of Medicine, 389 Xincun Road Shanghai, 200065, China; Department of Pharmacology, Tongji University School of Medicine, Shanghai, 200092, China.

Juan Wang (J)

Department of Ophthalmology of Tongji Hospital and Laboratory of Clinical and Visual Sciences of Tongji Eye Institute, Tongji University School of Medicine, 389 Xincun Road Shanghai, 200065, China.

Lixia Lu (L)

Department of Ophthalmology of Tongji Hospital and Laboratory of Clinical and Visual Sciences of Tongji Eye Institute, Tongji University School of Medicine, 389 Xincun Road Shanghai, 200065, China; Department of Biochemistry and Molecular Biology, Tongji University School of Medicine, Shanghai, 200092, China. Electronic address: lulixia@tongji.edu.cn.

Guo-Tong Xu (GT)

Department of Ophthalmology of Tongji Hospital and Laboratory of Clinical and Visual Sciences of Tongji Eye Institute, Tongji University School of Medicine, 389 Xincun Road Shanghai, 200065, China; Department of Pharmacology, Tongji University School of Medicine, Shanghai, 200092, China. Electronic address: gtxu@tongji.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Vieillissement de la cellule › Elimination of senescent cells inhibits...
questionsmedicales.fr › Équipement et fournitures › Milieux de culture › Milieux de culture conditionnés › Elimination of senescent cells inhibits...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Dasatinib › Elimination of senescent cells inhibits...
questionsmedicales.fr › Cellules › Cellules épithéliales › Elimination of senescent cells inhibits...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transdifférenciation cellulaire › Transition épithélio-mésenchymateuse › Elimination of senescent cells inhibits...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Elimination of senescent cells inhibits...
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Peroxyde d'hydrogène › Elimination of senescent cells inhibits...
questionsmedicales.fr › Maladies de l'oeil › Rétinopathies › Dégénérescence de la rétine › Dégénérescence maculaire › Elimination of senescent cells inhibits...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Flavonols › Quercétine › Elimination of senescent cells inhibits...
questionsmedicales.fr › Organes des sens › Oeil › Rétine › Épithélium pigmentaire de la rétine › Elimination of senescent cells inhibits...
questionsmedicales.fr › Facteurs biologiques › Pigments biologiques › Pigments rétiniens › Elimination of senescent cells inhibits...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Facteur de croissance transformant bêta › Elimination of senescent cells inhibits...