Accurate measurement of total and free testosterone levels for the diagnosis of androgen disorders.

Androgens Humans Male Sex Hormone-Binding Globulin / analysis Testosterone
SHBG bioavailable testosterone equilibrium dialysis hypogonadism liquid chromatography tandem mass spectrometry testosterone deficiency

Journal

Best practice & research. Clinical endocrinology & metabolism
ISSN: 1878-1594
Titre abrégé: Best Pract Res Clin Endocrinol Metab
Pays: Netherlands
ID NLM: 101120682

Informations de publication

Date de publication:
07 2022
Historique:
pubmed: 5 8 2022
medline: 9 9 2022
entrez: 4 8 2022
Statut: ppublish

Résumé

The circulating concentrations of total and free testosterone vary substantially in people over time due to biologic factors as well as due to measurement variation. Accurate measurement of total and free testosterone is essential for making the diagnosis of androgen disorders. Total testosterone should ideally be measured in a fasting state in the morning using a reliable assay, such as liquid chromatography tandem mass spectrometry, in a laboratory that is certified by an accuracy-based benchmark. Free testosterone levels should be measured in men in whom alterations in binding protein concentrations are suspected or in whom total testosterone levels are only slightly above or slightly below the lower limit of the normal male range for testosterone.

Identifiants

DOI: 10.1016/j.beem.2022.101683 PMID: 35927159
pubmed: 35927159
pii: S1521-690X(22)00070-7
doi: 10.1016/j.beem.2022.101683
pii:
doi:

Substances chimiques

Androgens 0
Sex Hormone-Binding Globulin 0
Testosterone 3XMK78S47O

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

101683

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Auteurs

Ezgi Caliskan Guzelce (EC)

Division of Endocrinology, Diabetes and Hypertension, Harvard Medical School, Brigham and Women's Hospital, 221 Longwood Avenue, RFB-2, Boston, MA, 02115, USA.

Francesca Galbiati (F)

Division of Endocrinology, Diabetes and Hypertension, Harvard Medical School, Brigham and Women's Hospital, 221 Longwood Avenue, RFB-2, Boston, MA, 02115, USA.

Anna L Goldman (AL)

Division of Endocrinology, Diabetes and Hypertension, Harvard Medical School, Brigham and Women's Hospital, 221 Longwood Avenue, RFB-2, Boston, MA, 02115, USA; Research Program in Men's Health: Aging and Metabolism, Brigham and Women's Hospital, Boston, MA, USA. Electronic address: algoldman1@bwh.harvard.edu.

Arijeet K Gattu (AK)

Division of Endocrinology, Diabetes and Hypertension, Harvard Medical School, Brigham and Women's Hospital, 221 Longwood Avenue, RFB-2, Boston, MA, 02115, USA.

Shehzad Basaria (S)

Division of Endocrinology, Diabetes and Hypertension, Harvard Medical School, Brigham and Women's Hospital, 221 Longwood Avenue, RFB-2, Boston, MA, 02115, USA; Research Program in Men's Health: Aging and Metabolism, Brigham and Women's Hospital, Boston, MA, USA.

Shalender Bhasin (S)

Division of Endocrinology, Diabetes and Hypertension, Harvard Medical School, Brigham and Women's Hospital, 221 Longwood Avenue, RFB-2, Boston, MA, 02115, USA; Research Program in Men's Health: Aging and Metabolism, Brigham and Women's Hospital, Boston, MA, USA; Boston Claude D. Pepper Older Americans Independence Center, Boston, MA, USA.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Hormones › Androgènes › Accurate measurement of total and free...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Accurate measurement of total and free...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › bêta-Globulines › Globuline de liaison aux hormones sexuelles › Accurate measurement of total and free...
questionsmedicales.fr › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Congénères de la testostérone › Testostérone › Accurate measurement of total and free...