Subversion of GBP-mediated host defense by E3 ligases acquired during Yersinia pestis evolution.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
04 08 2022
04 08 2022
Historique:
received:
20
04
2021
accepted:
18
07
2022
entrez:
4
8
2022
pubmed:
5
8
2022
medline:
9
8
2022
Statut:
epublish
Résumé
Plague has caused three worldwide pandemics in history, including the Black Death in medieval ages. Yersinia pestis, the etiological agent of plague, has evolved a powerful arsenal to disrupt host immune defenses during evolution from enteropathogenic Y. pseudotuberculosis. Here, we find that two functionally redundant E3 ligase of Y. pestis, YspE1 and YspE2, can be delivered via type III secretion injectisome into host cytosol where they ubiquitinate multiple guanylate-binding proteins (GBPs) for proteasomal degradation. However, Y. pseudotuberculosis has no such capability due to lacking functional YspE1/2 homologs. YspE1/2-mediated GBP degradations significantly promote the survival of Y. pestis in macrophages and strongly inhibit inflammasome activation. By contrast, Gbp
Identifiants
pubmed: 35927280
doi: 10.1038/s41467-022-32218-y
pii: 10.1038/s41467-022-32218-y
pmc: PMC9352726
doi:
Substances chimiques
Inflammasomes
0
Ubiquitin-Protein Ligases
EC 2.3.2.27
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4526Informations de copyright
© 2022. The Author(s).
Références
Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4864-9
pubmed: 19273841
Adv Exp Med Biol. 2016;918:193-222
pubmed: 27722864
J Bacteriol. 2010 Mar;192(6):1685-99
pubmed: 20061468
PLoS One. 2010 Dec 08;5(12):e15159
pubmed: 21170337
Infect Immun. 2003 Oct;71(10):5892-9
pubmed: 14500510
Nature. 2017 Nov 16;551(7680):378-383
pubmed: 29144452
Infect Immun. 2002 Aug;70(8):4092-8
pubmed: 12117916
Cell Host Microbe. 2012 Dec 13;12(6):799-805
pubmed: 23245324
Nat Immunol. 2006 Oct;7(10):1066-73
pubmed: 16980981
Infect Immun. 1993 Jan;61(1):23-31
pubmed: 8418045
Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):6046-51
pubmed: 24715728
Cell Host Microbe. 2017 Oct 11;22(4):507-518.e5
pubmed: 29024643
Infect Immun. 1986 Feb;51(2):445-54
pubmed: 3002984
Nature. 2011 Sep 14;477(7366):596-600
pubmed: 21918512
Cell Host Microbe. 2014 May 14;15(5):578-86
pubmed: 24832452
PLoS Pathog. 2017 Oct 2;13(10):e1006630
pubmed: 28968459
Int J Med Microbiol. 2002 Feb;291(6-7):455-62
pubmed: 11890544
Infect Immun. 2004 Sep;72(9):4973-84
pubmed: 15321989
Nat Struct Mol Biol. 2008 Dec;15(12):1293-301
pubmed: 18997778
Lancet. 2007 Apr 7;369(9568):1196-207
pubmed: 17416264
EMBO J. 1997 May 1;16(9):2307-18
pubmed: 9171345
Infect Immun. 1998 Dec;66(12):5755-62
pubmed: 9826351
Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13826-31
pubmed: 15358858
Nat Immunol. 2020 Aug;21(8):880-891
pubmed: 32541830
Mol Microbiol. 1994 Nov;14(3):583-94
pubmed: 7885236
Nat Rev Genet. 2019 Jun;20(6):323-340
pubmed: 30953039
Cell Host Microbe. 2017 Aug 9;22(2):166-175
pubmed: 28799902
Nat Immunol. 2015 May;16(5):443-4
pubmed: 25898190
J Leukoc Biol. 2018 Oct;104(4):729-735
pubmed: 30020539
Science. 2007 Jan 26;315(5811):509-13
pubmed: 17255510
Infect Immun. 2005 Nov;73(11):7142-50
pubmed: 16239508
Nat Immunol. 2015 May;16(5):476-484
pubmed: 25774716
Mol Cell Proteomics. 2021;20:100066
pubmed: 33631294
Nat Commun. 2015 Jun 30;6:7487
pubmed: 26123398
Mol Microbiol. 2000 Jul;37(2):316-30
pubmed: 10931327
Nature. 1988 Aug 11;334(6182):522-4
pubmed: 3043229
Proc Natl Acad Sci U S A. 2014 May 20;111(20):7385-90
pubmed: 24799700
PLoS One. 2013;8(1):e54121
pubmed: 23349800
Microbiol Mol Biol Rev. 1998 Dec;62(4):1315-52
pubmed: 9841674
Science. 1992 Nov 6;258(5084):1004-7
pubmed: 1439793
Cell Host Microbe. 2010 May 20;7(5):376-87
pubmed: 20478539
Immunity. 2012 Aug 24;37(2):191-3
pubmed: 22921115
J Genet Genomics. 2014 Jul 20;41(7):379-96
pubmed: 25064677
Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6640-5
pubmed: 10829079
Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12909-14
pubmed: 16120681
Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5526-30
pubmed: 16567636
Science. 2005 Sep 9;309(5741):1739-41
pubmed: 16051750
Nat Struct Mol Biol. 2008 Dec;15(12):1302-8
pubmed: 18997779
Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):14043-8
pubmed: 10570195
J Biol Chem. 2017 Mar 31;292(13):5488-5498
pubmed: 28196868
Clin Microbiol Rev. 1997 Jan;10(1):35-66
pubmed: 8993858
DNA Res. 2004 Jun 30;11(3):179-97
pubmed: 15368893
Infect Immun. 2006 Jun;74(6):3381-6
pubmed: 16714568
J Bacteriol. 2004 Aug;186(15):5147-52
pubmed: 15262951
Nat Immunol. 2016 May;17(5):481-9
pubmed: 27092805
Int J Med Microbiol. 2017 Jan;307(1):64-74
pubmed: 27876297
J Leukoc Biol. 2017 Jan;101(1):143-150
pubmed: 27418355
Nat Genet. 2010 Dec;42(12):1140-3
pubmed: 21037571
Curr Opin Microbiol. 2005 Feb;8(1):21-7
pubmed: 15694853
Science. 2002 Apr 26;296(5568):733-5
pubmed: 11976454
EMBO J. 1996 Oct 1;15(19):5191-201
pubmed: 8895564
Clin Immunol. 2005 Mar;114(3):216-26
pubmed: 15721832
Cell Host Microbe. 2016 Sep 14;20(3):296-306
pubmed: 27569559
Infect Immun. 2000 Jun;68(6):3419-25
pubmed: 10816493