Tumor microenvironmental signals reshape chromatin landscapes to limit the functional potential of exhausted T cells.
Journal
Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624
Informations de publication
Date de publication:
05 08 2022
05 08 2022
Historique:
entrez:
5
8
2022
pubmed:
6
8
2022
medline:
10
8
2022
Statut:
ppublish
Résumé
Response rates to immunotherapy in solid tumors remain low due in part to the elevated prevalence of terminally exhausted T cells, a hypofunctional differentiation state induced through persistent antigen and stress signaling. However, the mechanisms promoting progression to terminal exhaustion in the tumor remain undefined. Using the low-input chromatin immunoprecipitation sequencing method CUT&RUN, we profiled the histone modification landscape of tumor-infiltrating CD8
Identifiants
pubmed: 35930654
doi: 10.1126/sciimmunol.abj9123
pmc: PMC9851604
mid: NIHMS1841161
doi:
Substances chimiques
Chromatin
0
Histones
0
Jumonji Domain-Containing Histone Demethylases
EC 1.14.11.-
KDM6B protein, human
EC 1.14.11.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
eabj9123Subventions
Organisme : NIAID NIH HHS
ID : DP2 AI136598
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA082084
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI135027
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA047904
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA121973
Pays : United States
Organisme : NCI NIH HHS
ID : K00 CA222711
Pays : United States
Organisme : NCI NIH HHS
ID : F99 CA222711
Pays : United States
Organisme : NCI NIH HHS
ID : F30 CA247034
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI135367
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA097190
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI153104
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI089443
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008208
Pays : United States
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