From cyclins to CDKIs: Cell cycle regulation of skeletal muscle stem cell quiescence and activation.
CDK
CDKI
Cell cycle
Cyclins
Growth arrest
Muscle satellite cells
Muscle stem cells
Myogenesis
Proliferation
Quiescence
Skeletal muscle
Journal
Experimental cell research
ISSN: 1090-2422
Titre abrégé: Exp Cell Res
Pays: United States
ID NLM: 0373226
Informations de publication
Date de publication:
01 11 2022
01 11 2022
Historique:
received:
14
06
2021
revised:
12
06
2022
accepted:
03
07
2022
pubmed:
6
8
2022
medline:
28
9
2022
entrez:
5
8
2022
Statut:
ppublish
Résumé
After extensive proliferation during development, the adult skeletal muscle cells remain outside the cell cycle, either as post-mitotic myofibers or as quiescent muscle stem cells (MuSCs, also known as satellite cells). Despite its terminally differentiated state, adult skeletal muscle has a remarkable regeneration potential, driven by MuSCs. Upon injury, MuSC quiescence is reversed to support tissue growth and repair and it is re-established after the completion of muscle regeneration. The distinct cell cycle states and transitions observed in the different myogenic populations are orchestrated by elements of the cell cycle machinery. This consists of i) complexes of cyclins and Cyclin-Dependent Kinases (CDKs) that ensure cell cycle progression and ii) their negative regulators, the Cyclin-Dependent Kinase Inhibitors (CDKIs). In this review we discuss the roles of these factors in developmental and adult myogenesis, with a focus on CDKIs that have emerging roles in stem cell functions.
Identifiants
pubmed: 35931143
pii: S0014-4827(22)00268-3
doi: 10.1016/j.yexcr.2022.113275
pii:
doi:
Substances chimiques
Cyclins
0
Cyclin-Dependent Kinases
EC 2.7.11.22
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
113275Informations de copyright
Copyright © 2022. Published by Elsevier Inc.