Laparoscopic surgery for colorectal cancer in an elderly population with high comorbidity: a single centre experience.


Journal

International journal of colorectal disease
ISSN: 1432-1262
Titre abrégé: Int J Colorectal Dis
Pays: Germany
ID NLM: 8607899

Informations de publication

Date de publication:
Sep 2022
Historique:
accepted: 29 07 2022
pubmed: 6 8 2022
medline: 8 9 2022
entrez: 5 8 2022
Statut: ppublish

Résumé

The use of laparoscopic surgery for colorectal cancer in elderly patients with high comorbidity is a controversial subject. This retrospective analysis aims to compare two different age groups with respect to short and long term clinical and oncological outcomes. All laparoscopic colorectal resections for cancer performed between February 2011 and October 2017 with curative or palliative intention were evaluated. Among 128 completed resections, the rate of major complications, length of hospital stays, 30-day mortality, 2-year recurrence rate, and the survival after palliative surgery were comparable between group A (< 75 years; n = 76) and B (≥ 75 years; n = 52). Patients in group B showed an extraordinarily high proportion of ASA III stage (73.1% vs. A: 35.5%; p < 0.01) and, in this context, an increased rate of minor postoperative complications (17.3% vs. A: 6.6%; p < 0.05) and lower overall 2 and 5-year survival rates. Within the first 2 years, they died sooner in the event of recurrence (57.1% vs. A: 18.2%; p < 0.05), and their survival after rectal resection, especially for low rectal carcinoma, was significantly reduced (58.8% vs. A: 96.7%; p < 0.001). Laparoscopic surgery for colorectal cancer can be strongly advocated for elderly patients even in the face of high comorbidity. Whether very old patients with low rectal carcinoma also benefit from minimally invasive surgery or should undergo alternative therapies would need to be clarified primarily by examining the quality of life.

Identifiants

pubmed: 35931782
doi: 10.1007/s00384-022-04229-0
pii: 10.1007/s00384-022-04229-0
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1963-1973

Informations de copyright

© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Références

Lacy AM, Garcia-Valdecasas JC, Delgado S, Castells A, Taura P, Pique JM, Visa J (2002) Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomised trial. Lancet 359:2224–2229. https://doi.org/10.1016/s0140-6736(02)09290-5
doi: 10.1016/s0140-6736(02)09290-5 pubmed: 12103285
Ngu JCY, Kuo LJ, Teo NZ (2020) Minimally invasive surgery in the geriatric patient with colon cancer. J Gastrointest Oncol 11:540–544. https://doi.org/10.21037/jgo.2020.02.02
Croce E, Azzola M, Russo R, Golia M, Olmi S (1997) Laparoscopic colectomy: the absolute need for a standard operative technique. JSLS 1:217–224
pubmed: 9876674 pmcid: 3016731
Gong J, Shi DB, Li XX, Cai SJ, Guan ZQ, Xu Y (2012) Short-term outcomes of laparoscopic total mesorectal excision compared to open surgery. World J Gastroenterol 48:7308–7313. https://doi.org/10.3748/wjg.v18.i48.7308
doi: 10.3748/wjg.v18.i48.7308
Leitlinienprogramm Onkologie (Deutsche Krebsgesellschaft, Deutsche Krebshilfe, AWMF): S3-Leitlinie Kolorektales Karzinom, Langversion 2.1 (2019) AWMF-Registrierungsnummer: 021/007OL
Wittekind C, Tannapfel A (2003) Regression grading of colorectal carcinoma after preoperative radiochemotherapy. An inventory Pathologe 24:61–65. https://doi.org/10.1007/s00292-002-0602-9
doi: 10.1007/s00292-002-0602-9 pubmed: 12601479
Quirke P, Steele R, Monson J, Grieve R, Khanna S, Couture J, Callaghan CO, Myint AS, Bessell E, Thompson LC, Parmar M, Stephens RJ, Montefiore DS (2009) Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial. Lancet 373:821–828. https://doi.org/10.1016/s0140-6736(09)60485-2
doi: 10.1016/s0140-6736(09)60485-2 pubmed: 19269520 pmcid: 2668948
Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40:373–383. https://doi.org/10.1016/0021-9681(87)90171-8
doi: 10.1016/0021-9681(87)90171-8 pubmed: 3558716
Morneau M, Boulanger J, Charlebois P, Latulippe JF, Lougnarath R, Thibault C, Gervais N (2013) Laparoscopic versus open surgery for the treatment of colorectal cancer: a literature review and recommendations from the Comité de l’évolution des pratiques en oncologie. Can J Surg 56:297–310. https://doi.org/10.1503/cjs.005512
doi: 10.1503/cjs.005512 pubmed: 24067514 pmcid: 3788008
Veldkamp R, Kuhry E, Hop WCJ, Jeekel J, Kazemier G, Bonjer HJ, Haglind E, Pahlman L, Cuesta MA, Msika S, Morino M, Lacy AM (2005) Laparoscopic surgery versus open surgery for colon cancer: short-term outcomes of a randomised trial. Lancet Oncol 6:477–484. https://doi.org/10.1016/s1470-2045(05)70221-7
doi: 10.1016/s1470-2045(05)70221-7 pubmed: 15992696
Kuhry E, Schwenk W, Gaupset R, Romild U, Bonjer J (2008) Long-term outcome of laparoscopic surgery for colorectal cancer: a cochrane systematic review of randomised controlled trials. Cancer Treat Rev 34:498–504. https://doi.org/10.1016/j.ctrv.2008.03.011
doi: 10.1016/j.ctrv.2008.03.011 pubmed: 18468803
Blackmore AE, Ching Wong MT, Tang CL (2014) Evolution of laparoscopy in colorectal surgery: an evidence-based review. World J Gastroenterol 20:4926–4933. https://doi.org/10.3748/wjg.v20.i17.4926
doi: 10.3748/wjg.v20.i17.4926 pubmed: 24803804 pmcid: 4009524
Schlussel AT, Delaney CP, Maykel JA, Lustik MB, Nishtala M, Steele SR (2016) A national database analysis comparing the nationwide inpatient sample and American college of surgeons national surgical quality improvement program in laparoscopic vs open colectomies: inherent variance may impact outcomes. Dis Colon Rectum 59:843–854. https://doi.org/10.1097/DCR.0000000000000642
doi: 10.1097/DCR.0000000000000642 pubmed: 27505113
Stormark K, Søreide K, Søreide JA, Kvaløy JT, Pfeffer F, Eriksen MT, Nedrebø BS, Kørner H (2016) Nationwide implementation of laparoscopic surgery for colon cancer: short-term outcomes and long-term survival in a population-based cohort. Surg Endosc 30:4853–4864. https://doi.org/10.1007/s00464-016-4819-8
doi: 10.1007/s00464-016-4819-8 pubmed: 26905577
Chesney T, Acuna SA (2015) Do elderly patients have the most to gain from laparoscopic surgery? Ann Med Surg 4:321–323. https://doi.org/10.1016/j.amsu.2015.09.007
doi: 10.1016/j.amsu.2015.09.007
Ueda Y, Shiraishi N, Kawasaki T, Akagi T, Ninomiya S, Shiroshita H, Etoh T, Inomata M (2020) Short- and long-term outcomes of laparoscopic surgery for colorectal cancer in the elderly aged over 80 years old versus non-elderly: a retrospective cohort study. BMC Geriatr 20:445–454. https://doi.org/10.1186/s12877-020-01779-2
doi: 10.1186/s12877-020-01779-2 pubmed: 33148215 pmcid: 7641812
Damhuis RAM, Meurs CJC, Meijer WS (2005) Postoperative mortality after cancer surgery in octogenarians and nonagenarians: results from a series of 5,390 patients. World J Surg Oncol 3:71–78. https://doi.org/10.1186/1477-7819-3-71
doi: 10.1186/1477-7819-3-71 pubmed: 16280074 pmcid: 1298341
Sarikaya H, Benhidjeb T, Iosivan SI, Kolokotronis T, Förster C, Eckert S, Wilkens L, Nasser A, Rehberg S, Krüger M, Schulte am Esch J (2020) Impact of ASA-score, age and learning curve on early outcome in the initiation phase of an oncological robotic colorectal program. Sci Rep 10:15136. https://doi.org/10.1038/s41598-020-72025-3
Cai H, Zhang Y, Liu X, Jiang W, Chen Z, Li S, Guan G (2020) Association of age and cause-special mortality in patients with stage I/II colon cancer: a population based competing risk analysis. PloS One 15:e0240715. https://doi.org/10.1371/journal.pone.0240715
Neudecker J, Klein F, Bittner R, Carus T, Stroux A, Schwenk W (2009) Short-term outcomes from a prospective randomized trial comparing laparoscopic and open surgery for colorectal cancer. Br J Surg 96:1458–1467. https://doi.org/10.1002/bjs.6782
doi: 10.1002/bjs.6782 pubmed: 19918852
Neki K, Eto K, Kosuge M, Ohkuma M, Noaki R, Hashizume R, Sasaki S, Shirai Y, Yanaga K (2017) Comparison of postoperative outcomes between laparoscopic and open surgery for colorectal cancer. Anticancer Res 37:5173–5177. https://doi.org/10.21873/anticanres.11939
Nakao T, Shimada M, Yoshikawa K, Higashijima J, Tokunaga T, Nishi M, Takasu C, Kashihara H, Suzuka I, Nishizaki T, Okitsu H, Yagi T, Miyake H, Miura M, Fukuyama M, Wada D, Bando Y (2016) Propensity score-matched study of laparoscopic and open surgery for colorectal cancer in rural hospitals. J Gastroenterol Hepatol 31:1700–1704. https://doi.org/10.1111/jgh.13322
doi: 10.1111/jgh.13322 pubmed: 26896303
Zhou S, Wang X, Zhao C, Liu Q, Zhou H, Zheng Z, Zhou Z, Wang X, Liang J (2019) Laparoscopic vs open colorectal cancer surgery in elderly patients: short- and long-term outcomes and predictors for overall and disease-free survival. BMC Surg 19:137–144. https://doi.org/10.1186/s12893-019-0596-3
doi: 10.1186/s12893-019-0596-3 pubmed: 31521147 pmcid: 6744685
Dornquast C, Kroll LE, Neuhauser HK, Willich SN, Reinhold T, Busch MA (2016) Regional differences in the prevalence of cardiovascular disease – results from the German Health Update (GEDA) from 2009–2012. Dtsch Arztebl Int 113:704–711. https://doi.org/10.3238/arztebl.2016.0704
doi: 10.3238/arztebl.2016.0704 pubmed: 27866565 pmcid: 5143789
Arimoto A, Hasegawa H, Sugiyama H, Yamashita K, Matsuda T, Tominaga M, Sumi Y, Suzuki S, Kakeji Y (2017) Safety and effectiveness of laparoscopic colorectal resection in elderly patients with colorectal cancer: a propensity score matching study. Anticancer Res 37:4195–4198. https://doi.org/10.21873/anticanres.11809
Ishibe A, Ota M, Fujii S, Suwa Y, Suzuki S, Suwa H, Momiyama M, Watanabe J, Watanabe K, Taguri M, Kunisaki C, Endo I (2017) Midterm follow-up of a randomized trial of open surgery versus laparoscopic surgery in elderly patients with colorectal cancer. Surg Endosc 31:3890–3897. https://doi.org/10.1007/s00464-017-5418-z
doi: 10.1007/s00464-017-5418-z pubmed: 28205033
Planellas P, Salvador H, Cornejo L, Buxo M, Farres R, Molina X, Maroto A, Ortega N, Rodriguez-Hermosa JI, Codina-Cazador A (2020) Risk factors for suboptimal laparoscopic surgery in rectal cancer patients. Langenbecks Arch Surg. https://doi.org/10.1007/s00423-020-02029-0
doi: 10.1007/s00423-020-02029-0 pubmed: 33244719
Fürst A, Heiligensetzer A, Sauer P, Liebig-Hörl G (2014) Scientific evidence for laparoscopic rectal cancer surgery. Chirurg 578–582. https://doi.org/10.1007/s00104-014-2743-9
Majek O, Gondos A, Jansen L, Emrich K, Holleczek B, Katalinic A, Nennecke A, Eberle A, Brenner H (2012) Survival from colorectal cancer in Germany in the early 21
doi: 10.1038/bjc.2012.189 pubmed: 22555397 pmcid: 3364110
Diers J, Wagner J, Baum P, Lichthardt S, Kastner C, Matthes N, Matthes H, Germer CT, Löb S, Wiegering A (2020) Nationwide in-hospital mortality rate following rectal resection for rectal cancer according to annual hospital volume in Germany. BJS Open 4(2):310–319. https://doi.org/10.1002/bjs5.50254
doi: 10.1002/bjs5.50254 pubmed: 32207577 pmcid: 7093786
Lehmann KS, Klinger C, Diers J, Buhr HJ, Germer CT, Wiegering A (2021) Safety of anastomoses in colorectal cancer surgery in octogenarians: a prospective cohort study with propensity score matching. BJS Open. https://doi.org/10.1093/bjsopen/zrab102
doi: 10.1093/bjsopen/zrab102 pubmed: 34791030 pmcid: 8599068
Ng O, Watts E, Bull CA, Morris R, Acheson A, Banerjea A (2016) Colorectal cancer outcomes in patients aged over 85 years. Ann R Coll Surg Engl 98:216–221.  https://doi.org/10.1308/rcsann.2016.0085
Claassen YHM, Vermeer NCA, Iversen LH, van Eycken E, Guren MG, Mroczkowski P, Martling A, Cazador AC, Johansson R, Vandendae T, Wibe A, Moller B, Lippert H, Rutten HJT, Portielje JEA, Liefers GJ, Holman FA, van de Velde CJH, Bastiaannet E (2018) Treatment and survival of rectal cancer patients over the age of 80 years: a EURECCA international comparison. Br J Cancer 119:517–522. https://doi.org/10.1038/s41416-018-0215-6
doi: 10.1038/s41416-018-0215-6 pubmed: 30057408 pmcid: 6134121
Benz S, Barlag H, Gerken M, Fürst A, Klinkhammer-Schalke M (2017) Laparoscopic surgery in patients with colon cancer: a population-based analysis. Surg Endosc 31:2586–2595. https://doi.org/10.1007/s00464-016-5266-2
doi: 10.1007/s00464-016-5266-2 pubmed: 27704244

Auteurs

Gerald Drews (G)

Department of General, Visceral and Thoracic Surgery, Municipal Hospital Dessau, Städtisches Klinikum Dessau, and Brandenburg Medical School Theodor Fontane, Auenweg 38, 06847, Dessau, Germany. gerald.drews@klinikum-dessau.de.

Beatrix Bohnsteen (B)

Oncological Outpatient Department, Kastanienhof 1, 06847, Dessau, Germany.

Jürgen Knolle (J)

Institute of Pathology, Martha-Maria Hospital Halle-Dölau, Röntgenstraße 1, 06120, Halle (Saale), Germany.

Elise Gradhand (E)

Institute of Pathology, University Hospital, Theodor-Stern-Kai 7, 60590, Frankfurt/Main, Germany.

Peter Würl (P)

Department of General, Visceral and Thoracic Surgery, Municipal Hospital Dessau, Städtisches Klinikum Dessau, and Brandenburg Medical School Theodor Fontane, Auenweg 38, 06847, Dessau, Germany.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH