Rotational constriction of curcuminoids impacts 5-lipoxygenase and mPGES-1 inhibition and evokes a lipid mediator class switch in macrophages.

Arachidonate 5-Lipoxygenase / metabolism Constriction Curcumin / metabolism Diarylheptanoids / metabolism Eicosanoids / metabolism Humans Leukotrienes Lipoxygenase Inhibitors / pharmacology Macrophages / metabolism Molecular Docking Simulation Prostaglandin-E Synthases / antagonists & inhibitors Prostaglandins / metabolism
Curcumin Inflammation Leukotriene Lipid mediators Natural product Structure–activity relationship

Journal

Biochemical pharmacology
ISSN: 1873-2968
Titre abrégé: Biochem Pharmacol
Pays: England
ID NLM: 0101032

Informations de publication

Date de publication:
09 2022
Historique:
received: 18 05 2022
revised: 28 07 2022
accepted: 29 07 2022
pubmed: 7 8 2022
medline: 25 8 2022
entrez: 6 8 2022
Statut: ppublish

Résumé

Polypharmacological targeting of lipid mediator networks offers potential for efficient and safe anti-inflammatory therapy. Because of the diversity of its biological targets, curcumin (1a) has been viewed as a privileged structure for bioactivity or, alternatively, as a pan-assay interference (PAIN) compound. Curcumin has actually few high-affinity targets, the most remarkable ones being 5-lipoxygenase (5-LOX) and microsomal prostaglandin E

Identifiants

DOI: 10.1016/j.bcp.2022.115202 PMID: 35932797
pubmed: 35932797
pii: S0006-2952(22)00296-9
doi: 10.1016/j.bcp.2022.115202
pii:
doi:

Substances chimiques

Diarylheptanoids 0
Eicosanoids 0
Leukotrienes 0
Lipoxygenase Inhibitors 0
Prostaglandins 0
Arachidonate 5-Lipoxygenase EC 1.13.11.34
PTGES protein, human EC 5.3.99.3
Prostaglandin-E Synthases EC 5.3.99.3
Curcumin IT942ZTH98

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

115202

Informations de copyright

Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.

Auteurs

Zhigang Rao (Z)

Michael Popp Institute and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck 6020, Austria.

Diego Caprioglio (D)

Department of Drug Science, University of Piemonte Orientale, 28100 Novara, Italy.

André Gollowitzer (A)

Michael Popp Institute and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck 6020, Austria.

Christian Kretzer (C)

Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University Jena, Jena 07743, Germany.

Daniela Imperio (D)

Department of Drug Science, University of Piemonte Orientale, 28100 Novara, Italy.

Juan A Collado (JA)

Department of Cellular Biology, Physiology and Immunology, University of Cordoba, 14071, Cordoba, Spain; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), 14004, Cordoba, Spain; Hospital Universitario Reina Sofia, 14004, Cordoba, Spain.

Lorenz Waltl (L)

Michael Popp Institute and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck 6020, Austria.

Sandra Lackner (S)

Michael Popp Institute and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck 6020, Austria.

Giovanni Appendino (G)

Department of Drug Science, University of Piemonte Orientale, 28100 Novara, Italy.

Eduardo Muñoz (E)

Department of Cellular Biology, Physiology and Immunology, University of Cordoba, 14071, Cordoba, Spain; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), 14004, Cordoba, Spain; Hospital Universitario Reina Sofia, 14004, Cordoba, Spain.

Veronika Temml (V)

Institute of Pharmacy, Department of Pharmaceutical and Medicinal Chemistry, Paracelsus Medical University Salzburg, Salzburg 5020, Austria.

Oliver Werz (O)

Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University Jena, Jena 07743, Germany.

Alberto Minassi (A)

Department of Drug Science, University of Piemonte Orientale, 28100 Novara, Italy. Electronic address: alberto.minassi@uniupo.it.

Andreas Koeberle (A)

Michael Popp Institute and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck 6020, Austria. Electronic address: andreas.koeberle@uibk.ac.at.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Métalloprotéines › Protéines de liaison au fer › Protéines à fer non hème › Lipoxygénases › Arachidonate lipoxygenases › Arachidonate 5-lipoxygenase › Rotational constriction of curcuminoids...
questionsmedicales.fr › Techniques d'investigation › Constriction › Rotational constriction of curcuminoids...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Diarylheptanoïdes › Curcumine › Rotational constriction of curcuminoids...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Diarylheptanoïdes › Rotational constriction of curcuminoids...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Éicosanoïdes › Rotational constriction of curcuminoids...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Rotational constriction of curcuminoids...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Éicosanoïdes › Leucotriènes › Rotational constriction of curcuminoids...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de la lipoxygénase › Rotational constriction of curcuminoids...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Rotational constriction of curcuminoids...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Rotational constriction of curcuminoids...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Isomerases › Intramolecular oxidoreductases › Prostaglandin-E synthases › Rotational constriction of curcuminoids...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Éicosanoïdes › Prostaglandines › Rotational constriction of curcuminoids...