Comparative immunogenicity of an mRNA/LNP and a DNA vaccine targeting HIV
HIV
T cell response
antibody
conserved sequences
gag
immune focusing
mRNA/LNP
therapeutic immunization
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
16
05
2022
accepted:
24
06
2022
entrez:
8
8
2022
pubmed:
9
8
2022
medline:
10
8
2022
Statut:
epublish
Résumé
Immunogenicity of HIV-1 mRNA vaccine regimens was analyzed in a non-human primate animal model. Rhesus macaques immunized with mRNA in lipid nanoparticle (mRNA/LNP) formulation expressing HIV-1 Gag and Gag conserved regions (CE) as immunogens developed robust, durable antibody responses but low adaptive T-cell responses. Augmentation of the dose resulted in modest increases in vaccine-induced cellular immunity, with no difference in humoral responses. The
Identifiants
pubmed: 35935984
doi: 10.3389/fimmu.2022.945706
pmc: PMC9355630
doi:
Substances chimiques
AIDS Vaccines
0
Lipid Nanoparticles
0
Liposomes
0
RNA, Messenger
0
Vaccines, DNA
0
Vaccines, Synthetic
0
mRNA Vaccines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
945706Subventions
Organisme : NIAID NIH HHS
ID : P30 AI027757
Pays : United States
Informations de copyright
Copyright © 2022 Valentin, Bergamaschi, Rosati, Angel, Burns, Agarwal, Gergen, Petsch, Oostvogels, Loeliger, Chew, Deeks, Mullins, Pavlakis and Felber.
Déclaration de conflit d'intérêts
Authors JM, GP, BP and BF report issued patents of relevance to this work. Author MAn was employed by Leidos Biomedical Research, Inc. Authors JG, BP, LO, EL are employed by CureVac AG. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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