Mixed T Helper1/T Helper2/T Cytotoxic Profile in Subjects with Chronic Chagas Disease with Hypersensitivity Reactions to Benznidazole.
Trypanosoma cruzi
adverse drug reaction
benznidazole
Journal
Microbiology spectrum
ISSN: 2165-0497
Titre abrégé: Microbiol Spectr
Pays: United States
ID NLM: 101634614
Informations de publication
Date de publication:
31 08 2022
31 08 2022
Historique:
pubmed:
9
8
2022
medline:
9
9
2022
entrez:
8
8
2022
Statut:
ppublish
Résumé
Dermatitis is the most common adverse event during treatment with benznidazole in chronic Chagas disease and is probably mediated by T cells. A set of molecules representative of the different type IV hypersensitivity reactions was evaluated in the circulation and skin biopsies of Trypanosoma cruzi-infected subjects presenting dermatitis during benznidazole administration. Through cytometric bead assays and enzyme-linked immunosorbent assay capture techniques, the serum levels of cytokines, chemokines, proapoptotic molecules, and mediators of the activation and migration of eosinophils and T cells were measured in subjects infected with Trypanosoma cruzi who exhibited skin adverse events (
Identifiants
pubmed: 35938810
doi: 10.1128/spectrum.01357-22
pmc: PMC9430713
doi:
Substances chimiques
Nitroimidazoles
0
benzonidazole
YC42NRJ1ZD
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0135722Subventions
Organisme : NIAID NIH HHS
ID : R01 AI110346
Pays : United States
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