Changes of retinal structure and visual function in patients with demyelinating transverse myelitis.
Humans
Myelitis, Transverse
/ diagnostic imaging
Retrospective Studies
Cross-Sectional Studies
Autoantibodies
Aquaporin 4
Myelin-Oligodendrocyte Glycoprotein
Neuromyelitis Optica
/ diagnostic imaging
Optic Neuritis
/ diagnostic imaging
Retina
/ diagnostic imaging
Multiple Sclerosis
/ complications
Immunoglobulin G
Aquaporin-4-IgG-positive neuromyelitis optica spectrum disorder (NMOSD)
Multiple sclerosis
Myelin oligodendrocyte glycoprotein-associated disease (MOGAD)
Optic neuritis
Transverse myelitis
Journal
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
ISSN: 1590-3478
Titre abrégé: Neurol Sci
Pays: Italy
ID NLM: 100959175
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
received:
14
04
2022
accepted:
02
08
2022
pubmed:
9
8
2022
medline:
2
11
2022
entrez:
8
8
2022
Statut:
ppublish
Résumé
To identify the retina-structural and visual-functional alterations in the patients with aquaporin-4 (AQP4)-IgG-positive neuromyelitis optica spectrum disorder (NMOSD), myelin oligodendrocyte glycoprotein-associated disease (MOGAD), and multiple sclerosis (MS) patients, all of whom had demyelinating transverse myelitis (TM) without optic neuritis (ON). In this retrospective cross-sectional study, we reviewed the medical records of 97 patients, including 23 with AQP4-ON, 13 with AQP4-TM, 32 with MOG-ON, 3 with MOG-TM, 13 with MS-ON, and 13 with MS-TM. We measured the thickness of the retinal nerve fiber layer (RNFL) and the ganglion cell layer-inner plexiform layer (GCIPL) using optical coherence tomography to evaluate structural changes and compared these parameters with those of an age-matched healthy control. Functional outcomes were measured as visual acuity and mean deviation in visual field test. Mean RNFL and GCIPL thicknesses in all of the patients with TM were lower relative to the healthy control, while visual function was well preserved. Among the TM patients, RNFL thickness did not vary significantly among the groups, whereas GCIPL thickness in AQP4-TM and MS-TM was significantly lower than that in MOG-TM. All three TM groups showed significant mean RNFL reduction compared with the healthy control, whereas mean GCIPL thinning was evident only in AQP4-TM and MS-TM, not in MOG-TM. Patients with demyelinating TM incur retina-microstructural damage that varies by specific disease entity. Damage is distinct in AQP4-IgG-positive NMOSD and MS, but it is not so severe as to cause functional damage.
Identifiants
pubmed: 35939134
doi: 10.1007/s10072-022-06315-1
pii: 10.1007/s10072-022-06315-1
doi:
Substances chimiques
Autoantibodies
0
Aquaporin 4
0
Myelin-Oligodendrocyte Glycoprotein
0
Immunoglobulin G
0
Types de publication
Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6425-6431Subventions
Organisme : Seoul National University
ID : New Faculty Startup Fund
Informations de copyright
© 2022. Fondazione Società Italiana di Neurologia.
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