PREPARE trial: a protocol for a multicentre randomised trial of frailty-focused preoperative exercise to decrease postoperative complication rates and disability scores.

Aged Elective Surgical Procedures / rehabilitation Frailty / rehabilitation Humans Multicenter Studies as Topic Postoperative Complications / prevention & control Preoperative Exercise Quality of Life Randomized Controlled Trials as Topic
clinical trials geriatric medicine surgery

Journal

BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874

Informations de publication

Date de publication:
08 08 2022
Historique:
entrez: 8 8 2022
pubmed: 9 8 2022
medline: 11 8 2022
Statut: epublish

Résumé

Frailty is a strong predictor of adverse postoperative outcomes. Prehabilitation may improve outcomes after surgery for older people with frailty by addressing physical and physiologic deficits. The objective of this trial is to evaluate the efficacy of home-based multimodal prehabilitation in decreasing patient-reported disability and postoperative complications in older people with frailty having major surgery. We will conduct a multicentre, randomised controlled trial of home-based prehabilitation versus standard care among consenting patients >60 years with frailty (Clinical Frailty Scale Ethical approval has been granted by Clinical Trials Ontario (Project ID: 1785) and our ethics review board (Protocol Approval #20190409-01T). Results will be disseminated through presentation at scientific conferences, through peer-reviewed publication, stakeholder organisations and engagement of social and traditional media. NCT04221295.

Identifiants

DOI: 10.1136/bmjopen-2022-064165 PMID: 35940835 PMC: PMC9364396
pubmed: 35940835
pii: bmjopen-2022-064165
doi: 10.1136/bmjopen-2022-064165
pmc: PMC9364396
doi:

Banques de données

ClinicalTrials.gov
['NCT04221295']

Types de publication

Clinical Trial Protocol Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e064165

Investigateurs

Keely Barnes (K)
Sylvain Boet (S)
Laura Boland (L)
Karina Branje (K)
Rodney Breau (R)
Gregory L Bryson (GL)
Rosaleen Chun (R)
Irfan Dhalla (I)
Gary Dobson (G)
Elijah Dixon (E)
Antoine Eskander (A)
Alan Forster (A)
Hannah Frazer (H)
Sylvain Gagne (S)
Jayna Holroyd-Leduc (J)
Allen Huang (A)
Joanne Hutton (J)
Eric Jacobsohn (E)
John Joanisse (J)
Ana Johnson (A)
Stephanie Johnson (S)
Manoj M Lalu (MM)
Luke T Lavallee (LT)
Tien Le (T)
Susan Lee (S)
Cameron Love (C)
Grace Ma (G)
Colin McCartney (C)
Michael McMullen (M)
Husein Moloo (H)
Ronald Moore (R)
Thomas Mutter (T)
Sudhir Nagpal (S)
Julie Nantel (J)
Gregg Nelson (G)
Barbara Power (B)
Tarit Saha (T)
Celena Scheede-Bergdhal (C)
Pablo Serrano (P)
Laura Tamblyn-Watts (L)
Kednapa Thavorn (K)
Daniel Trottier (D)
Carl van Walraven (CV)
Brittany Warren (B)
Duminda Wijeysundera (D)
Ilun Yang (I)

Informations de copyright

© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Déclaration de conflit d'intérêts

Competing interests: None declared.

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Auteurs

Daniel I McIsaac (DI)

Anesthesiology and Pain Medicine, Ottawa Hospital Research Institute Clinical Epidemiology Program, Ottawa, Ontario, Canada dmcisaac@toh.ca.
ORCID: 0000-0002-8543-1859

Dean A Fergusson (DA)

Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
ORCID: 0000-0002-3389-2485

Rachel Khadaroo (R)

Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.

Amanda Meliambro (A)

Patient Engagement, Ottawa Hospital General Campus, Ottawa, Ontario, Canada.

John Muscedere (J)

Canadian Frailty Network, Kingston, Ontario, Canada.

Chelsia Gillis (C)

School of Human Nutrition, McGill University, Montreal, Quebec, Canada.

Emily Hladkowicz (E)

Anesthesiology and Pain Medicine, Ottawa Hospital Research Institute Clinical Epidemiology Program, Ottawa, Ontario, Canada.

Monica Taljaard (M)

Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.
ORCID: 0000-0002-3978-8961

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › PREPARE trial: a protocol for a multicentre...
questionsmedicales.fr › Procédures de chirurgie opératoire › Interventions chirurgicales non urgentes › PREPARE trial: a protocol for a multicentre...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fragilité › PREPARE trial: a protocol for a multicentre...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › PREPARE trial: a protocol for a multicentre...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études multicentriques comme sujet › PREPARE trial: a protocol for a multicentre...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Complications postopératoires › PREPARE trial: a protocol for a multicentre...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Services de santé › Soins aux patients › Soins périopératoires › Activité physique préopératoire › PREPARE trial: a protocol for a multicentre...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › État de santé › Qualité de vie › PREPARE trial: a protocol for a multicentre...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Essais cliniques comme sujet › Essais cliniques contrôlés comme sujet › Essais contrôlés randomisés comme sujet › PREPARE trial: a protocol for a multicentre...