Chromatin compaction precedes apoptosis in developing neurons.


Journal

Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179

Informations de publication

Date de publication:
08 08 2022
Historique:
received: 29 09 2021
accepted: 11 07 2022
entrez: 8 8 2022
pubmed: 9 8 2022
medline: 11 8 2022
Statut: epublish

Résumé

While major changes in cellular morphology during apoptosis have been well described, the subcellular changes in nuclear architecture involved in this process remain poorly understood. Imaging of nucleosomes in cortical neurons in vitro before and during apoptosis revealed that chromatin compaction precedes the activation of caspase-3 and nucleus shrinkage. While this early chromatin compaction remained unaffected by pharmacological blockade of the final execution of apoptosis through caspase-3 inhibition, interfering with the chromatin dynamics by modulation of actomyosin activity prevented apoptosis, but resulted in necrotic-like cell death instead. With super-resolution imaging at different phases of apoptosis in vitro and in vivo, we demonstrate that chromatin compaction occurs progressively and can be classified into five stages. In conclusion, we show that compaction of chromatin in the neuronal nucleus precedes apoptosis execution. These early changes in chromatin structure critically affect apoptotic cell death and are not part of the final execution of the apoptotic process in developing cortical neurons.

Identifiants

pubmed: 35941180
doi: 10.1038/s42003-022-03704-2
pii: 10.1038/s42003-022-03704-2
pmc: PMC9359995
doi:

Substances chimiques

Chromatin 0
Caspase 3 EC 3.4.22.-
Caspases EC 3.4.22.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

797

Informations de copyright

© 2022. The Author(s).

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Auteurs

Renata Rose (R)

Institute of Physiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

Nicolas Peschke (N)

Institute of Physiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

Elena Nigi (E)

Institute of Physiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

Márton Gelléri (M)

Institute of Molecular Biology gGmbH (IMB), Mainz, Germany.

Sandra Ritz (S)

Institute of Molecular Biology gGmbH (IMB), Mainz, Germany.

Christoph Cremer (C)

Institute of Molecular Biology gGmbH (IMB), Mainz, Germany.
Kirchhoff Institute for Physics (KIP), University of Heidelberg, Heidelberg, Germany.
Interdisciplinary Center for Scientific Computing (IWR), University of Heidelberg, Heidelberg, Germany.

Heiko J Luhmann (HJ)

Institute of Physiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany. luhmann@uni-mainz.de.

Anne Sinning (A)

Institute of Physiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany. asinning@uni-mainz.de.

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